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首页> 外文期刊>Developmental and Comparative Immunology: Ontogeny, Phylogeny, Aging: The Official Journal of the International Society of Developmental and Comparative Immunology >Larval exposure to bacteria modulates arbovirus infection and immune gene expression in adult Aedes aegypti
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Larval exposure to bacteria modulates arbovirus infection and immune gene expression in adult Aedes aegypti

机译：幼虫暴露于细菌调节成人AEDES AEGYPTI中的arbovirus感染和免疫基因表达

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摘要

Here we have investigated whether bacterial challenges to larval stages of Aedes aegypti can influence the adults' immune and vector competence for dengue and Zika viruses. We show that larval exposure to live Bacillus thuringiensis Berliner and Enterobacter luclwigii can result in the modulation of virus infection at the adult stage in the absence of bacterial carry-over between the two developmental stages. We observed a significant reduction in virus infection intensity in the mosquitoes exposed to bacteria as larvae but not re-exposed as adults. The pattern of immune gene transcript regulation after bacterial exposure varied between adults, depending on whether or not they had been exposed to bacteria as larvae. Adults exposed to bacteria as larvae showed an earlier immune gene mRNA enrichment when re-exposed as adults than did adults not exposed as larvae. Bacterial exposure of larvae appears to have only modest effects on adult fitness.
机译：在这里，我们研究了对AEGYPTI的幼虫阶段的细菌挑战是否可以影响登革热和ZIKA病毒的成年人的免疫和载体能力。 我们表明幼虫暴露于活杆菌芽孢杆菌和肠杆菌Luclwigii，可以导致在两种发育阶段之间没有细菌随身阶段的成人阶段对病毒感染的调节。 我们观察到蚊子中的病毒感染强度显着降低，暴露于细菌的幼虫，但没有作为成年人重新暴露。 在细菌暴露后的免疫基因转录物调节模式在成人之间变化，取决于它们是否被暴露于细菌作为幼虫。 暴露于细菌的成年人作为幼虫显示早期的免疫基因mRNA富集，当作为成年人被重新暴露而不是未暴露为幼虫的成年人。 幼虫的细菌暴露似乎对成人健康的影响仅适度。

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