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首页> 外文期刊>Drugs of today: Medicamentos de actualidad >MicroRNAs and microbiota: Is there a cross talk?
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MicroRNAs and microbiota: Is there a cross talk?

机译：microRNA和Microbiota：有骷髅吗？

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摘要

MicroRNAs (miRNAs) are a form of single-stranded RNA molecules with a length that varies between 18 and 23 nucleotides and which are synthesized in the nucleus but function in the cytoplasm. miRNAs function endogenously and bind to complementary sequences in either the coding regions or the 3' untranslated regions (UTRs) of target messenger RNAs (mRNAs). This indicates that miRNAs operate in a post-transcriptional manner. miRNAs play essential roles in various biological events, and have thus been found extracellularly in different body fluids such as saliva, urine and plasma. miRNAs are distinguished in the gut mainly by examining content from intestines and feces. The gastrointestinal tract is infested with a variety of microorganisms that are initially inherited from the mother; however, those microorganisms develop as a result of changes in dietary intake and environmental factors. The gut microbiota are therefore shaped differently in different individuals due to several contributing factors such as genetics, diet and state of disease, and have a great impact on the host during phases of disease and homeostasis.
机译：MicroRNA（miRNA）是一种单链RNA分子的形式，长度在18至23个核苷酸之间变化，并且在细胞核中合成但在细胞质中的作用。 MiRNAS内源性地函数，并在编码区域或目标信使RNA（MRNA）的3'未翻译区域（UTRS）中的互补序列结合。这表明miRNA以转录后的方式运行。 MiRNA在各种生物事件中起主要的作用，因此在不同的体液中发现了细胞外，如唾液，尿液和血浆。 MiRNA主要通过检查肠道和粪便的内容来区分肠道。胃肠道被最初从母亲继承的多种微生物感染;然而，这些微生物因饮食摄入和环境因素的变化而发展。因此，由于诸如遗传，饮食和疾病状态等若干有贡献因素，因此肠道微生物会形状不同的是不同的个体。

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