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首页> 外文期刊>Drugs of today: Medicamentos de actualidad >TERBINAFINE: NOVEL FORMULATIONS THAT POTENTIATE ANTIFUNGAL ACTIVITIES
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TERBINAFINE: NOVEL FORMULATIONS THAT POTENTIATE ANTIFUNGAL ACTIVITIES

机译：特拉布尼胺：具有抗真菌活性的新型制剂

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摘要

Terbinafine, an orally and topically active antifungal agent, has been available for the treatment of dermatophytic infections and onychomycosis for more than a decade. In addition, oral administration has been shown to be associated with drug-drug interactions, hepatotoxicity, low concentration at the infected sites, gastrointestinal and systemic side effects and other adverse effects. Since topical drug delivery can provide higher patient compliance, allow immediate access to the infected site and reduce unwanted systemic drug exposure, an improved topical drug delivery approach with high permeability, sustained release and prolonged retainment could overcome the limitations and side effects caused by oral administration. Conventional topical formulations cannot keep the drug in the targeted sites for a long duration of time and hence a novel drug delivery that can avoid the side effects while still providing sustained efficacy in treatment should be developed. This brief review of novel formulations based on polymers and nanostructure carriers provides insight into the efficacy and topical delivery of terbinafine.
机译：特拉哌嗪，口服和局部活性抗真菌剂，已用于治疗皮肤病感染和甲癣十多年。此外，已显示口服给药与药物 - 药物相互作用，肝毒性，低浓度在感染的位置，胃肠和全身副作用和其他不良反应相关。由于局部药物递送可以提供更高的患者依从性，因此可以立即进入受感染的部位并减少不需要的全身药物暴露，改善了具有高渗透性，持续释放和长期保留的改善的局部药物递送方法可以克服口服给药造成的限制和副作用。常规局部制剂不能使药物在靶位点中保持长时间的持续时间，因此可以避免副作用的新药递送，同时应开发仍然提供治疗持续疗效的同时。基于聚合物和纳米结构载体的新型配方简要介绍了洞察特贝林胺的疗效和局部递送。

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