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Keratitis in association with herpes zoster and varicella vaccines

机译：角膜炎与疱疹和水痘疫苗相关联

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摘要

The objective of this review was to collect reports of keratitis in association with herpes zoster virus (HZV) or varicella zoster virus (VZV) vaccines. HZV vaccination is intended for at-risk adult populations and VZV vaccination is intended for all pediatric patients. We reviewed the literature and reports of keratitis in association with herpes zoster or varicella vaccine from the National Registry of Drug-Induced Ocular Side Effects and the World Health Organization. Twenty-four cases of unilateral keratitis in association with VZV vaccines were collected from the adverse reaction databases and literature. In most cases, the onset of keratitis occurred within days of vaccination and resolved with topical steroid eye drops and oral acyclovir. Data suggest that keratitis in association with herpes zoster or varicella vaccine is rare, is usually self-limited or resolves with treatment. The mechanism may be the persistence of viral antigens in the cornea after VZV vaccination or herpes zoster ophthalmicus. This reaction is "probable," given the plausible biological mechanism, the temporal relationship between vaccination and keratitis, and overall patterns of presentation after vaccination.
机译：本综述的目的是收集与疱疹病毒（HZV）或水痘带状疱疹病毒（VZV）疫苗结合的角膜炎的报道。 HZV疫苗接种适用于风险的成人群体，VZV疫苗接种适用于所有儿科患者。我们审查了来自国家诱导眼部效应和世界卫生组织的国家登记处与疱疹病或水痘疫苗结合的角膜炎的文献和报告。从不良反应数据库和文献中收集了与VZV疫苗结合的二十四个单侧角膜炎。在大多数情况下，角膜炎的发作发生在疫苗接种的日子里，并用局部类固醇滴眼液和口服acyclovir解决。数据表明，与疱疹或水痘疫苗结合的角膜炎是罕见的，通常是自我限制的或用治疗解决。该机制可能是VZV疫苗接种或疱疹眼科后角膜病毒抗原的持续存在。鉴于合理的生物机制，疫苗接种和角膜炎之间的时间关系以及疫苗接种后的整体呈现模式，这种反应是“可能的”。

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