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Glecaprevir/pibrentasvir for the treatment of chronic hepatitis C virus infection in adults

机译：Glecaprevir / Pibrentasvir用于治疗成人慢性丙型肝炎病毒感染

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摘要

The fixed-dose combination of glecaprevir (GLE), a nonstructural protein 3/4A (NS3/4A) protease inhibitor, and pibrentasvir (PIB), an NS5A inhibitor, was recently approved for the treatment of adult patients with chronic hepatitis C virus (HCV) genotypes 1-6 (GT-1-6) without cirrhosis or with compensated cirrhosis, and for the treatment of HCV GT-1 patients who have failed treatment with either NS5A inhibitors or NS3/4A protease inhibitors, but not both. This combination, administered over 8 or 12 weeks, has resulted in high cure rates in all six HCV genotypes, including patients with HIV coinfection. GLE/PIB was well tolerated, with the most common adverse events being headache and fatigue. GLE/PIB is recommended to be taken as three tablets (total daily dose: GLE 300 mg and PIB 120 mg) orally once daily with food. No dose adjustment is required in patients with any degree of renal impairment or in patients undergoing hemodialysis. Dose adjustment is also not required in patients with Child-Pugh A liver disease. However, the use of GLE/PIB is not recommended in patients with moderate (Child-Pugh B) or severe (Child-Pugh C) hepatic impairment.
机译：Glecaprevir（GLE）的固定剂量组合，非结构蛋白3 / 4A（NS3 / 4A）蛋白酶抑制剂和PIBRENTASVIR（PIB），NS5A抑制剂最近被批准用于治疗慢性丙型肝炎病毒的成人患者（ HCV）基因型1-6（GT-1-6）没有肝硬化或用补偿肝硬化，以及治疗用NS5A抑制剂或NS3 / 4A蛋白酶抑制剂治疗失败的HCV GT-1患者，但并非两者。在8或12周内施用这种组合导致所有六种HCV基因型中的高固化率，包括艾滋病毒辛拷贝的患者。 GLE / PIB耐受良好，具有最常见的不良事件是头痛和疲劳。建议使用GLE / PIB作为三片（总日剂量：GLE 300mg和PIB 120mg），每日服用食物。任何肾损伤或血液透析患者都不需要剂量调节。儿童-PUGH肝病的患者也不需要剂量调节。然而，不建议使用适度（儿童PUGH B）或严重（儿童-PUGC）肝损伤的患者使用GLE / PIB的使用。

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