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首页> 外文期刊>Drug and alcohol review >Reducing diazepam prescribing for illicit drug users: a randomised control study.
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Reducing diazepam prescribing for illicit drug users: a randomised control study.

机译：减少用于非法吸毒者的Diazepam：随机对照研究。

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Illicit drug users undergoing mandatory reductions in prescribed diazepam were randomly allocated to one of two methods of delivering psychological support to help reduce their prescription: a) an enhanced intervention consisting of skills training and reinforcement, and b) a limited intervention where patients initially received skills training and thereafter only advice. Outcome measures at baseline and six-months consisted of daily diazepam dose; reported illicit drug use; Severity of Dependence Scale; Hospital Anxiety and Depression Scale (HADS); Pittsburgh Sleep Quality Index. Fifty-three of 119 eligible patients agreed to be randomly allocated to the interventions. Those in the enhanced intervention reduced their daily dose of prescribed diazepam from a mean of 27.8 mgs to 19.9 mgs at six months (5.3% per month) compared with 29.8 mgs to 17.6 mgs at six months (7.5%) among those in the limited intervention group. However, there was no statistically significant difference in the reduction rate between the intervention groups. Approximately 75% of patients in each group suspended their reduction programme. The enhanced intervention group reported a statistically and clinically greater reduction in the mean HADS depression score (10.6 at baseline and 7.7 at follow-up), compared with a rise from 8.9 to 11.2 in the limited intervention group. In conclusion, it is possible to reduce prescribed diazepam among illicit drug users but not at the rate of 10% per month set by the study. The difficulties of working with this population necessitate a flexible and possibly long-term approach to reducing prescribed benzodiazepines.
机译：经历在规定的Diazepam中进行强制性减少的非法药物被随机分配给提供心理支持的两种方法之一，以帮助减少其处方：a）由技能培训和强化组成的增强干预，以及患者最初获得技能的有限干预培训，此后只有建议。基线和六个月的结果措施由每日二氮酸泮剂量组成;报告非法药物使用;依赖范围的严重程度;医院焦虑和抑郁症（曾经）;匹兹堡睡眠质量指数。 119个符合条件的患者中的五十三名患者同意随机分配给干预措施。增强干预中的人在六个月（每月5.3％）（每月5.3％）的平均值将其每日服用二聚醇泮减少到19.9毫克的平均剂量，而干预有限六个月（7.5％），则为29.8毫克至17.6毫克。团体。但是，干预群之间的减少率没有统计学上显着差异。每组约75％的患者暂停了减少计划。增强的干预组在平均抑郁症评分（基线10.6和7.7时，在统计学上，临床上较大的减少，而在有限干预组中的8.9至11.2增加。总之，可以在非法吸毒者中减少规定的二聚醇蛋白，但不需要通过该研究的每月10％的速度。使用这群人群的困难需要灵活，并且可能是减少规定的苯并二氮杂卓的灵活性和可能的​​长期方法。

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