Xanthan Gum Coated Mucoadhesive Liposomes for Efficient Nose to Brain Delivery of Curcumin

Subodhkant Samudre; Avinash Tekade; Kanchan Thorve; Anup Jamodkar; Gauri Parashar Nilima Chaudhari

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Xanthan Gum Coated Mucoadhesive Liposomes for Efficient Nose to Brain Delivery of Curcumin

机译：黄原胶涂层粘膜粘附性脂质体，以有效的鼻子脑递送姜黄素

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Background: The objective of this study was to develop liposomal mucoadhesive drag delivery system for the delivery of curcumin via nasal route, to avoid hepatic first pass metabolism, to increase residence time and to investigate its nose to brain delivery potential.Methodology: The liposomes were prepared by solvent dispersion method using soya lecithin and cholesterol as a lipid phase and xanthan gum as a mucoadhesive polymer.

机译：背景：本研究的目的是开发脂质体粘膜粘附拖曳递送系统，用于通过鼻途径递送姜黄素，以避免肝脏首次通过代谢，增加停留时间并调查其脑递送潜力。方法：脂质体：脂质体通过溶剂分散方法使用大豆卵磷脂和胆固醇作为脂质相和黄原胶作为粘膜粘附聚合物制备。

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来源
《Drug delivery letters》 |2015年第3期|共7页
作者
Subodhkant Samudre; Avinash Tekade; Kanchan Thorve; Anup Jamodkar; Gauri Parashar Nilima Chaudhari;
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作者单位

Post Graduate Department of Pharmaceutics JSPMs Rajarshi Shahu College of Pharmacy and Research;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Curcumin; liposomes; mucoadhesion; nose to brain delivery; solvent dispersion method; xanthan gum.;

机译：姜黄素;脂质体;粘膜粘附;鼻子脑递送;溶剂分散法;黄原胶。;

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1. Xanthan Gum Coated Mucoadhesive Liposomes for Efficient Nose to Brain Delivery of Curcumin [J] . Subodhkant Samudre, Avinash Tekade, Kanchan Thorve, Drug delivery letters . 2015,第3期

机译：黄原胶涂层粘膜粘附性脂质体，以有效的鼻子脑递送姜黄素
2. Liposomes coated with chitosan-xanthan gum (chitosomes) as potential carriers for pulmonary delivery of rifampicin. [J] . Manca ML, Manconi M, Valenti D, Journal of pharmaceutical sciences. . 2012,第2期

机译：涂有壳聚糖-黄原胶的脂质体（壳聚糖）作为利福平肺部递送的潜在载体。
3. Chitosan-coated liposome dry-powder formulations loaded with ghrelin for nose-to-brain delivery [J] . Salade Laurent, Wauthoz Nathalie, Vermeersch Marjorie, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2018,第期

机译：壳聚糖涂层的脂质体干粉配方，加载鼻子鼻蛋白，用于鼻部递送
4. Konjac Glucomannan and Xanthan Gum as Compression Coat for Colonic Drug Delivery:Experimental and Theoretical Evaluations [C] . Wang Kang, Fan Jiangyang, Liu Yanjun, Proceedings of international symposium on crystal engineering and drug delivery system 2009 . 2009

机译：魔芋葡甘露聚糖和黄原胶作为结肠给药的压缩外套：实验和理论评价
5. Fabrication and Characterization of a Targeted, Coated Cationic Liposome for Delivery of Double-Stranded miRNA-146a Mimic to Diseased Endothelial Cells in Atherosclerosis [D] . Wang, Kening. 2018

机译：靶向和包被的阳离子脂质体的制备和表征，用于将双链miRNA-146a模拟物递送至动脉粥样硬化中的病变内皮细胞
6. Development of coated liposomes loaded with ghrelin for nose-to-brain delivery for the treatment of cachexia [O] . Laurent Salade, Nathalie Wauthoz, Magali Deleu, 2017

机译：开发了生长激素释放肽的包衣脂质体用于从鼻到脑的输送以治疗恶病质
7. Significance of QbD in design and development of coated liposomes for nose to brain delivery [O] . Fakhara Sabir, Ildikó Csóka 2020

机译：QBD在脑送到脑部分娩时涂层脂质体的设计和开发的意义

Xanthan Gum Coated Mucoadhesive Liposomes for Efficient Nose to Brain Delivery of Curcumin

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