HIV Drug Resistance Mutations in Non-B Subtypes After Prolonged Virological Failure on NNRTI-Based First-Line Regimens in Sub-Saharan Africa

Kityo Cissy; Thompson Jennifer; Nankya Immaculate; Hoppe Anne; Ndashimye Emmanuel; Warambwa Colin; Mambule Ivan; van Oosterhout Joep J.; Wools-Kaloustian Kara; Bertagnolio Silvia; Easterbrook Philippa J.; Mugyenyi Peter; Walker A. Sarah; Paton Nicholas I.

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HIV Drug Resistance Mutations in Non-B Subtypes After Prolonged Virological Failure on NNRTI-Based First-Line Regimens in Sub-Saharan Africa

机译：撒哈拉以南非洲新赤兰第一线方案延长病毒故障后非B亚型中的HIV毒性突变

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Objective: To determine drug resistance mutation (DRM) patterns in a large cohort of patients failing nonnucleoside reverse transcriptase inhibitor (NNRTI)-based first-line antiretroviral therapy regimens in programs without routine viral load (VL) monitoring and to examine intersubtype differences in DRMs.

机译：目的：确定在没有常规病毒载荷（VL）监测的程序中，在没有常规病毒载量（VL）监测的方案中，在未核苷逆转录酶抑制剂（NNRTI）的大核苷逆转录酶抑制剂（NNRTI）的患者中的患者的大群群体中的毒性突变（DRM）模式。。

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来源
《JAIDS: Journal of acquired immune deficiency syndromes》 |2017年第2期|共10页
作者
Kityo Cissy; Thompson Jennifer; Nankya Immaculate; Hoppe Anne; Ndashimye Emmanuel; Warambwa Colin; Mambule Ivan; van Oosterhout Joep J.; Wools-Kaloustian Kara; Bertagnolio Silvia; Easterbrook Philippa J.; Mugyenyi Peter; Walker A. Sarah; Paton Nicholas I.;
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作者单位

JCRC Kampala Uganda;

UCL MRC Clin Trials Unit London England;

JCRC Kampala Uganda;

UCL MRC Clin Trials Unit London England;

JCRC Kampala Uganda;

Univ Zimbabwe Clin Res Ctr Harare Zimbabwe;

Infect Dis Inst Kampala Uganda;

Univ Malawi Coll Med Malawi Liverpool Wellcome Trust Clin Res Programme Blantyre Malawi;

Moi Univ Sch Med Dept Med Eldoret Kenya;

WHO Geneva Switzerland;

WHO Geneva Switzerland;

JCRC Kampala Uganda;

UCL MRC Clin Trials Unit London England;

UCL MRC Clin Trials Unit London England;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
HIV; drug resistance; drug resistance mutations; non-B subtype; Africa; first-line failure;

机译：艾滋病毒;耐药;耐药突变;非B亚型;非洲;一线失败;

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专利

1. HIV Drug Resistance Mutations in Non-B Subtypes After Prolonged Virological Failure on NNRTI-Based First-Line Regimens in Sub-Saharan Africa [J] . Kityo Cissy, Thompson Jennifer, Nankya Immaculate, JAIDS: Journal of acquired immune deficiency syndromes . 2017,第2期

机译：撒哈拉以南非洲新赤兰第一线方案延长病毒故障后非B亚型中的HIV毒性突变
2. Accumulation of HIV-1 drug resistance after continued virological failure on first-line ART in adults and children in sub-Saharan Africa [J] . Boender T. Sonia, Kityo Cissy M., Boerma Ragna S., The Journal of Antimicrobial Chemotherapy . 2016,第10期

机译：撒哈拉以南非洲成年人和儿童在一线抗病毒药物持续病毒学失败后HIV-1耐药性的累积
3. Accumulation of HIV-1 drug resistance after continued virological failure on first-line ART in adults and children in sub-Saharan Africa [J] . Boender T. Sonia, Kityo Cissy M., Boerma Ragna S., The Journal of Antimicrobial Chemotherapy . 2016,第10期

机译：撒哈拉非洲成人和儿童持续病毒学失败后持续病毒故障后的HIV-1耐药性积累
4. Automatic Detection of HIV Drug Resistance-Associated Mutations [C] . Cheng Betty Y., Carbonell Jaime G. Ninth International Conference on Machine Learning and Applications . 2010

机译：自动检测HIV耐药相关突变
5. Intracellular drug -drug interaction between nucleoside analogs leads to early virologic failure in HIV patients receiving triple nucleoside combinations of tenofovir, lamivudine and abacavir or didanosine. [D] . Bi, Lucun. 2007

机译：核苷类似物之间的细胞内药物相互作用会导致接受替诺福韦，拉米夫定和阿巴卡韦或二羟肌苷的三核苷组合的HIV患者出现早期病毒学衰竭。
6. HIV Drug Resistance Mutations in Non-B Subtypes After Prolonged Virological Failure on NNRTI-Based First-Line Regimens in Sub-Saharan Africa [O] . Cissy Kityo, Jennifer Thompson, Immaculate Nankya, -1

机译：撒哈拉以南非洲基于NNRTI的一线方案长期病毒学失败后非B型亚型的HIV耐药性突变
7. HIV drug resistance mutations in non-B subtypes after prolonged virological failure on NNRTI-based first-line regimens in sub-Saharan Africa [O] . Kityo, C, Thompson, J, Nankya, I, 2017

机译：撒哈拉以南非洲基于NNRTI的一线方案长期病毒学失败后，非B型亚型的HIV耐药性突变

HIV Drug Resistance Mutations in Non-B Subtypes After Prolonged Virological Failure on NNRTI-Based First-Line Regimens in Sub-Saharan Africa

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