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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Trends in prescriptions for highly active antiretroviral therapy in four New York City HIV clinics.
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Trends in prescriptions for highly active antiretroviral therapy in four New York City HIV clinics.

机译：四个纽约市艾滋病毒诊所中高活性抗逆转录病毒治疗处方趋势。

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摘要

OBJECTIVE: To describe trends in prescriptions for antiretroviral therapies and factors associated with prescriptions for highly active antiretroviral therapy (HAART). METHODS: Medical records of patients at four HIV clinics in New York City were reviewed every 6 months. For the four 6-month periods 1997 to 1998, we identified patients with a CD4+ nadir <500 cells/microl; sample sizes were 434, 432, 503, and 643, respectively. Trends in HAART prescriptions were tested by logistic regression using robust variance estimates because some patients contributed more than one time period. Associations between HAART prescriptions and patient characteristics were tested by chi2 and multiple logistic regression analysis. RESULTS: Patients were predominantly black or Hispanic (89%-90%) and male (66%-68%), and injection drug use was the most prevalent HIV risk (38%-49%). From 1997 to 1998, HAART prescriptions increased from 54% to 89% of antiretroviral prescriptions, and the proportion that included an nonnucleoside reverse transcriptase inhibitors (NNRTI) increased from 3% to 10%. HAART prescriptions were inversely associated with CD4+ nadir group during all time periods, and in the second half of 1998, patients with CD4+ nadir between 50 and 199 cells/microl were as likely to be prescribed HAART as the most immunosuppressed patients (CD4+ nadir <50 cells/microl; 91% versus 92%). HAART prescriptions were associated with clinic, HIV risk, and other patient characteristics in some time periods but not consistently. CONCLUSIONS: In these four HIV clinics, prescriptions for HAART increased significantly from 1997 to 1998, leveling off at 89% in the second half of 1998. Increasingly, HAART was prescribed for healthier patients and included an NNRTI.
机译：目的：描述抗逆转录病毒疗法处方的趋势和与高活性抗逆转录病毒治疗（HAART）的处方相关的因素。方法：纽约市四个艾滋病毒诊所患者的病程每6个月审查。对于1997年至1998年的四个月期间，我们鉴定了CD4 + Nadir <500细胞/微醇的患者;样品尺寸分别为434,432,503和643。利用鲁棒方差估算的逻辑回归测试了HAART处方的趋势，因为一些患者贡献了多个时间。 HAART处方和患者特征之间的关联得到CHI2和多重逻辑回归分析。结果：患者主要是黑色或西班牙裔（89％-90％）和雄性（66％-68％），注射药物使用是最普遍的艾滋病毒风险（38％-49％）。从1997年到1998年，HAART处方从抗逆转录病毒处方的54％增加到89％，其中包括非核苷逆转录酶抑制剂（NNRTI）的比例从3％增加到10％。 HAART处方与CD4 + Nadir组在所有时间段期间与CD4 + Nadir组相关，并且在1998年下半年50至199个细胞/微醇的患者可能被规定为HAART作为最具免疫抑制的患者（CD4 + Nadir <50细胞/微醇; 91％对92％）。 HAART处方与临床，艾滋病毒风险和其他患者特征在一段时间内与其他患者特征有关，但并不一致。结论：在这四种艾滋病毒诊所，1997年至1998年的HAART规定在1998年下半年升级89％，越来越多地为更健康患者开展，包括一个NNRTI。

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