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Anxiolytic properties of cannabidiol

机译：大麻抗氧性特性

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Cannabidiol (CBD) is a nonintoxicating compound present in the Cannabis sativa plant and evidence of its therapeutic utility is increasing. In fact, CBD is already being used as therapy in various neurologic conditions and other potential usages are under investigation. The aim of this review is to summarize current knowledge on CBD's usefulness as a therapeutic agent in anxiety disorders. The cannabinoid's anxiolytic profile has been demonstrated in different rodent models as well as in humans, the first proof consisting of its ability to reverse Delta 9-tetrahydrocannabinol (THC)-induced anxiety. Although recent experiments suggest CBD does not reduce emotional responses to negative stimuli, a large body of evidence argues the compound is anxiolytic in several anxiety models. CBD's actions seem mainly mediated via 5-HT1A receptor potentiation and the cannabinoid is also thought to partially act through interaction with the endocannabinoid system, possibly by inhibiting anandamide's metabolism. Moreover, neuroimaging studies have put forward that CBD specifically acts on limbic and paralimbic brain areas. Lastly, CBD is known to activate the anxiogenic transient receptor potential vanilloid receptor 1 (TRPV1), which may explain its inverted U-shape dose-response curve. Considered generally safe, this cannabinoid embodies a promising anxiolytic agent.
机译：大麻（CBD）是在大麻苜蓿植物中存在的不氧化化合物，其治疗效用的证据正在增加。事实上，CBD已经被用作各种神经系统条件下的治疗，并且正在调查其他潜在用途。本综述的目的是总结当前关于CBD的有用性作为焦虑症的治疗剂的知识。在不同的啮齿动物模型以及人类中，大麻素的抗焦虑型已经证明了一种由其逆转δ9-四氢甘油（THC）引起的焦虑的能力组成的第一证据。虽然最近的实验表明CBD不会减少对负刺激的情绪反应，但大量证据表明该化合物在几种焦虑模型中是抗焦虑。 CBD的作用似乎主要通过5-HT1A受体升级介导，并且本麻素也被认为是通过与内胆碱系统的相互作用部分作用，可能是通过抑制Aandamide的新陈代谢。此外，神经影像学研究提出了CBD专门对肢体和普拉维尼脑区的作用。最后，已知CBD激活焦炭发生瞬时受体潜在的香草素受体1（TRPV1），其可以解释其倒置的U形剂量 - 响应曲线。认为通常是安全的，这种大麻素体现了有充满希望的抗焦虑药。

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