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Rationale of the potential role of lithium in the antiaging arena

机译：锂在抗凝竞技场中潜在作用的理由

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Lithium is the mainstay treatment in the management of bipolar disorder. A growing body of findings suggests that lithium could be considered a neuroprotective agent that might slow the progression of neurobiological abnormalities in Alzheimer's disease and possibly in other neurodegenerative disorders. Additionally, the effect of lithium on telomere length, as well as the increased overall survival associated with microdoses of lithium in drinking water, led to hypothesize that lithium might have "antiaging" properties. In this review, we summarize available evidence from preclinical and clinical studies investigating the potential beneficial effects of lithium in the antiaging arena and in neurodegenerative disorders, as well as the putative underlying molecular mechanisms, including inhibition of the glycogen synthase kinase-3 (GSK-3) enzyme, reduction of oxidative stress and counteraction of telomere shortening. Additionally, we present a timely overview of currently active clinical trials that might enhance our understanding of the beneficial properties of lithium and highlight the potential for drug repurposing.
机译：锂是双相障碍管理中的主要处理。越来越多的研究结果表明，锂可能被认为是一种神经保护剂，可能会减缓阿尔茨海默病患者的神经生物学异常的进展，并且可能在其他神经变性障碍中。另外，锂对端粒长度的影响，以及与饮用水中锂微量化相关的总体存活率的影响导致锂锂可能具有“抗衰析”性能。在本综述中，我们总结了来自临床前和临床研究的可用证据，调查锂在抗衰级竞技场和神经变性障碍中的潜在有益效果，以及推定的潜在的分子机制，包括抑制糖原合酶激酶-3（GSK- 3）酶，降低氧化应激和端粒缩短的反应。此外，我们及时概述目前活跃的临床试验，可能会提高我们对锂的有益特性的理解，并突出药物重新施用的潜力。

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