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首页> 外文期刊>JAMA otolaryngology-- head & neck surgery >Evolution of Altered Sense of Smell or Taste in Patients With Mildly Symptomatic COVID-19
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Evolution of Altered Sense of Smell or Taste in Patients With Mildly Symptomatic COVID-19

机译：温和症状Covid-19患者患者嗅觉或味道改变的演变

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Importance An altered sense of smell and taste has been reported to be associated with coronavirus disease 2019 (COVID-19). To understand the evolution of these symptoms during the course of the disease is important to identify patients with persistent loss of smell or taste and estimate the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the burden of olfactory and gustative dysfunctions. Objective To evaluate the evolution of the loss of sense of smell and taste in a case series of mildly symptomatic patients with SARS-CoV-2 infection. Design, Setting, and Participants This cross-sectional survey-based study included 202 mildly symptomatic adults (>= 18 years) consecutively assessed at Treviso Regional Hospital, Italy, between March 19 and March 22, 2020, who tested positive for SARS-CoV-2 RNA by polymerase chain reaction on nasopharyngeal and throat swabs. Main Outcomes and Measures Prevalence of altered sense of smell and taste at follow-up and their variation from baseline. Results Of 202 patients completing the survey at baseline, 187 (92.6%) also completed the follow-up survey (103 [55.1%] women; median age, 56 years). The evaluation of the evolution of altered sense of smell or taste in the 113 patients reporting sudden onset of these symptoms at baseline showed that 55 patients (48.7%; 95% CI, 39.2-58.3) reported complete resolution of smell or taste impairment, 46 (40.7%; 95% CI, 31.6-50.4) reported an improvement in the severity, and only 12 (10.6%; 95% CI, 5.6-17.8) reported the symptom was unchanged or worse. Persistent loss of smell or taste was not associated with persistent SARS-CoV-2 infection. Conclusions and Relevance At 4 weeks from the onset, 89% of the SARS-CoV-2-positive mildly symptomatic patients who had had a sudden onset of altered sense of smell or taste experienced a complete resolution or improvement of these symptoms. Persistent loss of smell or taste was not associated with persistent SARS-CoV-2 infection.
机译：据报道，重要的味道和味道的改变感与冠状病毒2019（Covid-19）有关。要了解这些症状在疾病过程中的演变对于鉴定患有血液丧失或味道的患者，估计严重急性呼吸综合征冠状病毒2（SARS-COV-2）感染对嗅负担的影响是重要的。令人困难的功能障碍。目的探讨SARS-COV-2感染案例系列患者味道损失和味道损失的演变。设计，设定和参与者这种基于横断面调查的研究包括在202年3月19日至3月22日至3月22日之间的Treviso地区医院（> = 18岁），于2020年3月22日至3月22日，他们测试了SARS-COV的阳性-2通过聚合酶链反应对鼻咽癌和喉拭子的RNA。主要成果和措施改变嗅觉和随访的味道的患病率及其从基线的变化。结果202例患者在基线完成调查，187名（92.6％）还完成了后续调查（103 [55.1％]妇女;中位年龄，56岁）。在基线报告这些症状突​​然发作的113名患者中改变嗅觉或味道的演变的评价显示，55名患者（48.7％; 95％CI，39.2-58.3）报告了嗅觉或味道损伤的完全解决，46 （40.7％; 95％CI，31.6-50.4）报告了严重程度的改善，只有12个（10.6％; 95％CI，5.6-17.8）报告了症状不变或更糟。持续的气味或味道丧失与持续的SARS-COV-2感染无关。结论和相关性在发病4周，89％的SARS-COV-2阳性症状患者突然发生了变化的嗅觉或味道的突然发作，经历了完整的解决方案或改善这些症状。持续的气味或味道丧失与持续的SARS-COV-2感染无关。

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