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首页> 外文期刊>Journal of Analytical Toxicology >Forensic Drug Profile: Cocaethylene
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Forensic Drug Profile: Cocaethylene

机译：法医药物：CoCaethylene

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摘要

This article is intended as a brief review or primer about cocaethylene (CE), a pharmacologically active substance formed in the body when a person co-ingests ethanol and cocaine. Reference books widely used in forensic toxicology contain scant information about CE, even though this cocaine metabolite is commonly encountered in routine casework. CE and cocaine are equi-effective at blocking the reuptake of dopamine at receptor sites, thus reinforcing the stimulant effects of the neurotransmitter. In some animal species, the LD50 of CE was lower than for cocaine. CE is also considered more toxic to the heart and liver compared with the parent drug cocaine. The plasma elimination half-life of CE is similar to 2 h compared with similar to 1 h for cocaine. The concentrations of CE in blood after drinking alcohol and taking cocaine are difficult to predict and will depend on the timing of administration and the amounts of the two precursor drugs ingested. After an acute single dose of cocaine and ethanol, the concentration-time profile of CE runs on a lower level to that of cocaine, although CE is detectable in blood for several hours longer. A strong case can be made for adding together the concentrations of cocaine and CE in forensic blood samples when toxicological results are interpreted in relation to acute intoxication and the risk of an overdose death.
机译：本文旨在作为环丙烯（Ce）的简要审查或底漆，当一个人共同摄取乙醇和可卡因时在体内形成的药理活性物质。广泛用于法医学毒理学的参考书包含关于CE的Scant信息，即使这个可卡因代谢物通常在常规案例中常见。 Ce和可卡因在阻止受体位点的再摄取多巴胺的再摄取，从而强化神经递质的兴奋效。在一些动物物种中，CE的LD50低于可卡因。与母体药物可卡因相比，CE也被对心脏和肝脏的毒性更毒性。 CE的血浆消除半衰期与2小时相似，而可卡因的1小时相比。饮酒后血液中的血液浓度难以预测，并取决于给药的时间和摄入两种前体药物的量。在急性单剂量的可卡因和乙醇之后，CE的浓度时间曲线在较低水平上运行到可卡因的较低水平，尽管CE在血液中可检测到几个小时的时间更长。当毒理学结果被解释为急性中毒和过量死亡的风险时，可以使得在法医血液样本中的可卡因和Ce的浓度一起加入强烈的情况。

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