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首页> 外文期刊>Journal of Animal Physiology and Animal Nutrition >Phospholipid compositions of sera and synovial fluids from dog, human and horse: a comparison by pdp#P-NMR and MALDI-TOF MS
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Phospholipid compositions of sera and synovial fluids from dog, human and horse: a comparison by pdp#P-NMR and MALDI-TOF MS

机译：来自狗，人和马的血清和滑膜液的磷脂组合物：PDP＃P-NMR和MALDI-TOF MS的比较

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摘要

Alterations of the phospholipid (PL) compositions of body fluids are assumed to be indicative of inflammatory diseases, e.g. rheumatoid arthritis (RA). Recently, we have shown that particularly the phosphatidylcholine/lysophosphatidylcholine (PC/LPC) ratio determined in human synovial fluids (SF) and sera represents a reliable measure of the inflammatory state in RA patients. However, it is not yet clear to what extent the PC/LPC ratio is also affected by nutrition habits. In the present study, the PL and the corresponding acyl chain compositions of human body fluids (SF and serum of RA patients as well as serum from healthy volunteers) are compared with those of two other mammalian species (horses and dogs suffering from degenerative joint diseases as well as healthy controls) by high-resolution pdp#P-nuclear magnetic resonance (NMR) spectroscopy and matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS). The most important result of this study is that the PL compositions of SF and serum of horse and dog are comparable with those of human body fluids. Compared with humans, however, the horse body fluid contains less PCs with highly unsaturated arachidonoyl residues, while that of dogs possesses the highest content of arachidonoyl-containing PC. These species-related differences stem primarily from different nutrition habits (meat vs. plants).
机译：假设体液的磷脂（PL）组合物的改变指示炎性疾病，例如炎性疾病。类风湿性关节炎（RA）。最近，我们已经表明，特别是人类滑液（SF）和血清中测定的磷脂基胆碱/溶血磷酰胆碱（PC / LPC）比代表了RA患者炎症状态的可靠测量。但是，目前尚不清楚PC / LPC比率在多大程度上也受营养习性的影响。在本研究中，与另外两种哺乳动物物种（马匹和患有退行性关节疾病的马匹和狗的RA患者和RA患者的SF和RA患者血清以及来自健康志愿者的RA患者的血清的相应酰基链条组合物通过高分辨率PDP＃核磁共振（NMR）光谱和基质辅助激光解吸和电离飞行时间质谱（MALDI-TOF MS）的健康控制。本研究的最重要结果是马和狗的SF和血清的Pl组成与人体流体的Pl。然而，与人类相比，马体液含有较少的PC，具有高度不饱和的花生酰核残留物，而狗的含量最高的含含量的PC。这些与物种相关的差异主要来自不同的营养习惯（肉类与植物）。

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