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首页> 外文期刊>Journal of applied physiology >Relationship between brachial and popliteal artery low-flow-mediated constriction in older adults: impact of aerobic fitness on vascular endothelial function
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Relationship between brachial and popliteal artery low-flow-mediated constriction in older adults: impact of aerobic fitness on vascular endothelial function

机译：老年人肱动脉和Popliteal动脉低流量介导的关系：有氧健身对血管内皮功能的影响

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We previously observed that brachial artery (BA) low-flow-mediated constriction (L-FMC) is inversely related to aerobic fitness (i.e., O-2peak) in older adults (OA). However, it is unclear if an L-FMC response is elicited in the popliteal artery (POP) or if a similar inverse relationship with aerobic fitness exists. Considering that the POP experiences larger shear stress fluctuations during sedentary behaviors and traditional lower limb modes of aerobic exercise, we tested the hypotheses that 1) heterogeneous L-FMC responses exist between the BA versus POP of OA, and 2) that aerobic fitness will be inversely related to POP L-FMC. L-FMC was assessed in 47 healthy OA (30 women, 67 +/- 5 yr) using duplex ultrasonography and quantified as the percent decrease in diameter (from baseline) during the last 30 s of a 5-min distal cuff occlusion period. When allometrically scaled to baseline diameter, the BA exhibited a greater L-FMC response than the POP (-1.3 +/- 1.6 vs. -0.4 +/- 1.6%; P = 0.03). Furthermore, L-FMC responses in the BA and POP were not correlated (r = 0.22; P = 0.14). O-2peak was strongly correlated to POP L-FMC (r = -0.73; P O-2peak and POP L-FMC suggests that localized shear stress patterns, perhaps induced by lower limb dominant modes of aerobic exercise, may result in greater vasoconstrictor responsiveness in healthy OA.
机译：我们之前观察到，肱动脉（BA）低流量介导的收缩（L-FMC）与老年人（OA）中的有氧健身（即O-2Peak）与有氧健身（即O-2Peak）相反。然而，如果在Popliteal动脉（POP）中引发了L-FMC响应，或者存在与有氧健身相似的反相关系，则尚不清楚。考虑到POP经历久坐行为和传统的有氧运动的传统下肢模式的剪力压力波动，我们测试了1）非均质L-FMC响应在OA的BA与oa和2）之间存在的假设，并且是有氧的健身与POP L-FMC相反。在5分钟的远​​端袖带闭塞期间，使用双链超声检查在47个健康的OA（30名女性，67 +/- 5 YR）中评估了47名健康OA（30名女性，67 +/- 5 YR），并将直径减小（从基线从基线）进行量化。当以基线直径分组缩放时，BA呈现比POP的更大的L-FMC响应（-1.3 +/- 1.6与-0.4 +/- 1.6％; p = 0.03）。此外，BA和POP中的L-FMC应答不相关（r = 0.22; p = 0.14）。 O-2Peak与POP L-FMC强烈相关（R = -0.73; P O-2Peak和Pop L-FMC表明，局部剪切应力模式，可能是由低肢体主导锻炼模式诱导的，可能导致更大的血管收缩剂响应性在健康的OA。

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