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首页> 外文期刊>Journal of applied toxicology >Effect of sulphur mustard inhalation exposure on some urinary variables in mice.
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Effect of sulphur mustard inhalation exposure on some urinary variables in mice.

机译：硫磺芥末吸入暴露对小鼠一些尿辨率的影响。

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摘要

The effect of sulphur mustard (2,2'-dichlorodiethyl sulphide) exposure through inhalation at 0.5. 1.0 and 2.0 LC50 (21.2, 42.3 and 84.6 mg m(-3) for 1 h) on some urinary variables was studied in female mice at 6, 24 and 48 h and 7 days post-exposure. The urinary excretion and circulatory blood accumulation of uric acid increased significantly. The level of creatine was also elevated significantly as compared to the control at 2 LC50. It is concluded that sulphur mustard alkylates DNA and triggers catabolism of apurinated purine bases in a very short time. The increase in uric acid excretion in urine can be detected only when the exposure concentration is high.
机译：硫磺芥菜（2,2'-二氯二乙基硫化物）通过吸入的影响0.5。 在暴露后6,24和48小时和7天的雌性小鼠中研究了1.0和2.0 LC50（21.2，42.3和84.6mg mg mg mg m（-3 mg m（-3）在雌性小鼠中进行了雌性小鼠和暴露后7天。 尿酸的尿排泄和循环血液积累显着增加。 与2LC50的对照相比，肌酸水平也显着升高。 结论是，硫芥末烷基化物DNA并在很短的时间内触发纯嘌呤碱的分解代谢。 只有当曝光浓度高时，尿液中尿酸排泄的增加也可以检测。

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