Catalpol protects against 2,3,7,8‐tetrachlorodibenzo‐ p p ‐dioxin‐induced cytotoxicity in osteoblastic MC3T3‐E1 cells

Choi Eun Mi; Suh Kwang Sik; Jung Woon‐Won; Yun Soojin; Park So Young; Chin Sang Ouk; Rhee Sang Youl; Chon Suk

首页> 外文期刊>Journal of applied toxicology >Catalpol protects against 2,3,7,8‐tetrachlorodibenzo‐ p p ‐dioxin‐induced cytotoxicity in osteoblastic MC3T3‐E1 cells

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Catalpol protects against 2,3,7,8‐tetrachlorodibenzo‐ p p ‐dioxin‐induced cytotoxicity in osteoblastic MC3T3‐E1 cells

机译：Catalpol在成骨细胞MC3T3-E1细胞中保护2,3,7,8-四氯二苯并苯-dioxin诱导的细胞毒性

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Abstract 2,3,7,8tetrachlorodibenzop dioxin (TCDD) is a wellknown environmental contaminant that produces a wide variety of adverse effects in humans. Catalpol, a major bioactive compound enriched in the dried root ofRehmannia glutinosa , is a major iridoid glycoside that alleviates bone loss. However, the detailed mechanisms underlying the effects of catalpol remain unclear. The present study evaluated the effects of catalpol on TCDDinduced cytotoxicity in osteoblastic MC3T3E1 cells. Catalpol inhibited TCDDinduced reduction in cell viability and increases in apoptosis and autophagic activity in osteoblastic MC3T3E1 cells. Additionally, pretreatment with catalpol significantly decreased the nitric oxide and nitrite levels compared with a control in TCDDtreated cells and significantly inhibited TCDDinduced increases in the levels of cytochrome P450 1A1 and extracellular signalregulated kinase. Pretreatment with catalpol also effectively restored the expression of superoxide dismutase and extracellular signalregulated kinase 1 and significantly enhanced the expression of glutathione peroxidase 4 and osteoblast differentiation markers, including alkaline phosphatase and osterix. Taken together, these findings demonstrate that catalpol has preventive effects against TCDDinduced damage in MC3T3E1 osteoblastic cells.

机译：摘要2,3,7,8-Tethlorodibenzop Dioxin（TCDD）是一种众所周知的环境污染，可在人类中产生各种不利影响。 Catalpol是一种富含干根谷氨酸的主要生物活性化合物，是一种可减轻骨质损失的主要紫烷醇糖苷。然而，目录效果的详细机制仍然不清楚。本研究评估了催化剂对骨细胞MC3T3E1细胞中TCDdd诱导细胞毒性的影响。 Catalpol抑制细胞活力的降低，骨细胞MC3T3E1细胞中的细胞凋亡和自噬活性增加。另外，与TCDTREATED细胞中的对照相比，具有催化剂的预处理显着降低了一氧化氮和亚硝酸盐水平，并且显着抑制细胞色素P450 1A1和细胞外信号调节激酶水平的TCDDDd诱导增加。用催化剂的预处理还有效地恢复了超氧化物歧化酶和细胞外信号传导激酶1的表达，并显着增强了谷胱甘肽过氧化物酶4和成骨细胞分化标志物的表达，包括碱性磷酸酶和Ostorix。这些研究结果表明，Catalpol对MC3T3E1骨细胞细胞中对TCDd诱导损伤具有预防作用。

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来源
《Journal of applied toxicology》 |2019年第12期|共10页
作者
Choi Eun Mi; Suh Kwang Sik; Jung Woon‐Won; Yun Soojin; Park So Young; Chin Sang Ouk; Rhee Sang Youl; Chon Suk;
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作者单位

Department of Endocrinology &

Metabolism College of MedicineKyung Hee UniversitySeoul Republic of;

Department of Endocrinology &

Metabolism College of MedicineKyung Hee UniversitySeoul Republic of;

Department of Biomedical Laboratory Science College of Health SciencesCheongju UniversityCheongju;

Department of Medicine Graduate SchoolKyung Hee UniversitySeoule Republic of Korea;

Department of Endocrinology &

Metabolism College of MedicineKyung Hee UniversitySeoul Republic of;

Department of Endocrinology &

Metabolism College of MedicineKyung Hee UniversitySeoul Republic of;

Department of Endocrinology &

Metabolism College of MedicineKyung Hee UniversitySeoul Republic of;

Department of Endocrinology &

Metabolism College of MedicineKyung Hee UniversitySeoul Republic of;

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正文语种 eng
中图分类毒物学（毒理学）;
关键词
2; 3; 7; 8tetrachlorodibenzo p dioxin; catalpol; differentiation; osteoblast;

机译：2;3;7;8Tethlorodibenzo p Dioxin;催化;分化;成骨细胞;

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1. Catalpol protects against 2,3,7,8‐tetrachlorodibenzo‐ p p ‐dioxin‐induced cytotoxicity in osteoblastic MC3T3‐E1 cells [J] . Choi Eun Mi, Suh Kwang Sik, Jung Woon‐Won, Journal of applied toxicology . 2019,第11a12期

机译：Catalpol在成骨细胞MC3T3-E1细胞中保护2,3,7,8-四氯二苯并苯-dioxin诱导的细胞毒性
2. Actein alleviates 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated cellular dysfunction in osteoblastic MC3T3-E1 cells [J] . Eun Mi Choi, Kwang Sik Suh, Woon-Won Jung, Environmental toxicology . 2017,第11a12期

机译：肌动蛋白减轻成骨细胞MC3T3-E1细胞中2,3,7,8-四氯二苯并-p-二恶英介导的细胞功能障碍
3. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced cytotoxicity accompanied by oxidative stress in rat Sertoli cells: Possible role of mitochondrial fractions of Sertoli cells. [J] . Aly HA, Khafagy RM Toxicology and Applied Pharmacology . 2011,第3期

机译：2,3,7,8-四氯二苯并-对-二恶英（TCDD）诱导的细胞毒性并伴随氧化应激的大鼠支持细胞：支持细胞线粒体组分的可能作用。
4. Induction of Growth Arrest and DNA Damage-Inducible Genes in Human Hepatoma HepG2 Cells by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) [C] . Yanqun Liu, Yikai Zhou Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009 . 2009

机译：2,3,7,8-四氯二苯并-p-二恶英（TCDD）在人肝癌HepG2细胞中诱导生长停滞和DNA损伤诱导基因
5. Mechanisms for 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated effects on CD40 ligand-induced activation and effector function of primary human and mouse B cells [D] . Lu, Haitian 2010

机译：2,3,7,8-四氯二苯并-p-二恶英介导的对CD40配体诱导的人和小鼠B细胞活化和效应子功能的作用机理
6. IL‐10 induces MC3T3‐E1 cells differentiation towards osteoblastic fate in murine model [O] . Yuan Xiong, Chenchen Yan, Lang Chen, 2020

机译：IL-10在鼠模型中诱导MC3T3-E1细胞分化为成骨细胞
7. Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis [O] . Hong Lu, Wei Cui, Curtis D. Klaassen 2011

机译：NRF2保护2,3,7,8-四氯二苯并苯并二恶英（TCDD）诱导氧化损伤和脱脂性炎
8. Disposition of 2,3,7,8-Tetrabromodibenzo-p-Dioxin and 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Rat: Biliary Excretion and Induction of Cytochromes CYP1A1 and CYP1A2 [R] . Kedderis, L. B., Diliberto, J. J., Linko, P., 1992

机译：大鼠2,3,7,8-四溴二苯并对二恶英和2,3,7,8-四氯二苯并对二恶英的配置：细胞色素CYp1a1和CYp1a2的胆汁排泄和诱导

Catalpol protects against 2,3,7,8‐tetrachlorodibenzo‐ p p ‐dioxin‐induced cytotoxicity in osteoblastic MC3T3‐E1 cells

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