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首页> 外文期刊>Journal of applied toxicology >Comparison of tris(2‐ethylhexyl) phosphate and di(2‐ethylhexyl) phosphoric acid toxicities in a rat 28‐day oral exposure study
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Comparison of tris(2‐ethylhexyl) phosphate and di(2‐ethylhexyl) phosphoric acid toxicities in a rat 28‐day oral exposure study

机译：三（2-乙基己基）磷酸酯和二（2-乙基己基）磷酸毒性的比较28天口服暴露研究

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摘要

Abstract Tris(2‐ethylhexyl) phosphate (TEHP, CAS no. 78‐42‐2) is a plasticizer and a flame retardant, while di(2‐ethylhexyl) phosphoric acid (DEHPA, CAS no. 298‐07‐7) is an oil additive and extraction solvent. Publicly‐available information on repeated exposure to these two related organophosphate compounds is fragmentary. Hence, adult male and female Fischer rats were exposed to TEHP (300, 1000 and 3000 mg/kg body weight [BW]/day) or DEHPA (20, 60 and 180 mg/kg BW/day) by gavage for 28 consecutive days, to assess and compare their toxicities. Although significantly impaired BW gains and evidence of TEHP enzymatic hydrolysis to DEHPA were observed only in males, exposures to the highest TEHP and DEHPA doses often resulted in similar alterations of hematology, serum clinical chemistry and liver enzymatic activities in both males and females. The squamous epithelial hyperplasia and hyperkeratosis observed in the non‐glandular forestomach of rats exposed to the middle and high DEHPA doses were most likely caused by the slightly corrosive nature of this chemical. Although tubular degeneration and spermatid retention were observed only in the testes of males exposed to the highest TEHP dose, numerous periodic acid‐Schiff stained crystalline inclusions were observed in testis interstitial cells at all TEHP dose levels. No‐observed‐adverse‐effect levels for TEHP and DEHPA are proposed, but the lower serum pituitary hormone levels resulting from TEHP and DEHPA exposures and the perturbations of testicular histology observed in TEHP‐treated males deserve further investigation. Improved characterization of the toxicity of flame retardants will contribute to better informed substitution choices for legacy flame retardants phased‐out over health concerns.
机译：摘要Tris（2-乙基己基）磷酸盐（Tehp，CAS No.78-42-2）是增塑剂和阻燃剂，而DI（2-乙基己基）磷酸（DEHPA，CAS NO.298-07-7）是油添加剂和萃取溶剂。关于这两个相关的有机磷酸酯化合物反复暴露的公开信息是零碎的。因此，通过Gavage连续28天将成年雄性和雌性费氏大鼠暴露于Tehp（300,1000和3000mg / kg体重[BW] /日）或DEHPA（20,60和180mg / kg / kg /天） ，评估和比较他们的毒性。虽然在雄性中观察到BW增益和Tehp酶水解的证据，但仅在雄性中观察到DehPa，最高的Tehp和Dehpa剂量的曝光通常导致血液学，血清临床化学和肝脏酶活性的相似改变。在暴露于中间和高DEHPA剂量暴露于中高DEHPA剂量的大鼠非腺体林苗中观察到的鳞状上皮增生和高曲目症最有可能由这种化学品的略微腐蚀性引起。虽然仅在暴露于最高Tehp剂量的雄性睾丸中仅观察到管状退化和精菌保留，但在所有Tehp剂量水平的睾丸间质细胞中观察到许多核酸 - 席夫染色的结晶夹杂物。提出了Tehp和Dehpa的无观察到的 - 不良效应水平，但是由Tehp和Dehpa暴露产生的血清垂体激素水平和在Tehp治疗的雄性中观察到的睾丸组织学的扰动值得进一步调查。改善了阻燃剂的毒性的表征将有助于更好地了解遗留阻燃剂的替代选择逐步过健康问题。

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