...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of applied toxicology >The neonicotinoids acetamiprid and imidacloprid impair neurogenesis and alter the microglial profile in the hippocampal dentate gyrus of mouse neonates
【24h】

The neonicotinoids acetamiprid and imidacloprid impair neurogenesis and alter the microglial profile in the hippocampal dentate gyrus of mouse neonates

机译：Neonicotinoids acetamiprid和咪酰啉潜水腺损害神经发生，并改变小鼠新生儿的海马齿状齿状物中的微胶质曲线

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Acetamiprid (ACE) and imidacloprid (IMI) are widely used neonicotinoid pesticides. They bind selectively to insect nicotinic acetylcholine receptors (nAChRs) and are considered nonhazardous to mammals. Few studies have assessed the activation of vertebrate nAChRs and the neurodevelopmental toxicity following in utero or neonatal exposure to neonicotinoids; therefore, we evaluated the effects of ACE or IMI exposure on neurogenesis and microglial profiles in the developing hippocampal dentate gyrus (DG) of mouse neonates. Mice were exposed to ACE, IMI (both 5爉g/kg/day) or nicotine (0.5爉g/kg/day) from postnatal day (P)12 to P26 by oral gavage. On P27, brains were removed, and neurogenesis and microglial activation in the hippocampal DG were examined via immunohistochemistry. A reduction in neurogenesis in the hippocampal DG of neonates following ACE, IMI and nicotine treatment was found. Additionally, neonicotinoidexposed newborns showed an increase in the number of amoeboidtype and activated M1type microglia. These results suggest that exposure to ACE and IMI impairs neurogenesis and alters microglial profiles in the developing hippocampal DG following oral dosing in an early postnatal period. A better understanding of the potential effects of these pesticides on human infant health is an important goal of our research.
机译：摘要acetamiprid（ace）和咪酰基啉（IMI）是广泛使用的新烟碱蛋白杀虫剂。它们选择性地与昆虫烟碱乙酰胆碱受体（NACHRS）结合，并被认为是非危害的哺乳动物。少数研究评估了在子宫或新生儿暴露于Neonicotinoids中的脊椎动物NACHRS和神经发育毒性的激活;因此，我们评估了ACE或IMI暴露对神经发生和小鼠新生儿的发育海马齿状转酯（DG）中的神经发生和微胶质谱的影响。通过口服饲养将小鼠暴露于从后期（P）12至P26的后期（P）12至P26的ACE，IMI（均为5‰G / kg /天）或尼古丁（0.5±g / kg /天）。在P27上，除去大脑，通过免疫组化检查海马DG中的神经发生和微胶质激活。发现了在Ace，IMI和尼古丁治疗后的新生儿的海马DG中神经发生的降低。此外，新生儿的新生儿表现出amoeboidpe和活化的M1型微胶质的数量增加。这些结果表明，暴露于ACE和IMI损害神经发生和改变在产后早期口服给药后发育海马DG中的微胶质谱。更好地了解这些农药对人类婴儿健康的潜在影响是我们研究的重要目标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号