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首页> 外文期刊>Journal of applied toxicology >Structure-pulmonary toxicity/retention relationships of inhaled fluorocyclobutenes.
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Structure-pulmonary toxicity/retention relationships of inhaled fluorocyclobutenes.

机译：吸入氟环丁烯的结构 - 肺毒性/保留关系。

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Hexafluorocyclobutene (HFCB) and derivatives have been used as fumigants, refrigerants and polymerization monomers. When inhaled they produce a potentially fatal pulmonary oedema similar to that induced by perfluoroisobutene (PFIB), a by-product of Teflon manufacture. This study determined the relationship between the chemical structure, respiratory retention and toxicity of HFCB and five analogues in rats and mice. Retention in the rat was determined using a flow-through system combining nose-only exposure and plethysmography. Structural changes to HFCB modified retention. At concentrations of ca. 1 ppm, where uptake was independent of exposure time, the rate of uptake was increased by halogen substitution in the order 3-Br = 1-Br = 1-Cl > 3-Cl = 1-H > HFCB, and was a function of volatility. At concentrations of 6 or 30 ppm, the percentage retained and rate of uptake decreased with time. The total mass retained (micromol kg(-1)) was not proportional to inhaled concentration and was best described by the calculated partition coefficient (octane-water). No clear relationship between retention and reactivity was apparent. The contribution of volatility, partition coefficient and reactivity to the uptake process depended on inhaled concentration. The toxicity of the fluorocyclobutenes agreed with reactivity relationships based on electrophilicity (lowest unoccupied molecular orbital energy), carbanion stability and leaving-group mobility. Toxicity is based principally on the number of successive alkylations (1, 2 or 3) that can occur with tissue nucleophiles.
机译：六氟环丁烯（HFCB）和衍生物已被用作熏蒸剂，制冷剂和聚合单体。当吸入时，它们产生类似于由全氟异丁烯（PFIB）诱导的Teflon制造的副产物的潜在致命的肺水肿。该研究确定了大鼠和小鼠中HFCB和五种类似物的化学结构，呼吸保留和毒性之间的关系。使用仅结合鼻子的曝光和体检的流通系统测定大鼠中的保留。 HFCB修改保留的结构变化。在CA的浓度。 1 ppm，其中摄取与暴露时间无关，在3-br = 1-br = 1-cl> 3-cl = 1-H> HFCB的顺序中通过卤素取代增加，增加了摄取率，并且是一个函数挥发性。在6或30 ppm的浓度下，保留的百分比和摄取率随时间降低。保留的总质量（微摩尔kg（-1））与吸入浓度成比例，并且最好通过计算的分配系数（辛烷水）描述。保留和反应性之间没有明显的关系是显而易见的。对吸入过程的波动性，分配系数和反应性的贡献取决于吸入浓度。含氟环丁烯的毒性与基于电泳（最低未占用的分子能量），碳膨胀稳定性和离开群体流动性的反应性关系。毒性主要基于组织亲核试剂可以发生的连续烷基化（1,2或3）的数量。

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