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首页> 外文期刊>Journal of applied toxicology >Different effects of polycyclic aromatic hydrocarbons in artificial and in environmental mixtures on the free living nematode G elegans
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Different effects of polycyclic aromatic hydrocarbons in artificial and in environmental mixtures on the free living nematode G elegans

机译：多环芳烃在人工和环境混合物中的不同含量和环境混合物的不同效果

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ABSTRACT: Polycyclic aromatic hydrocarbons (PAHs) are known to exert mutagenic and carcinogenic effects. Research on extracted organic matter (EOM) from environmental mixtures has indicated several mechanisms of intracellular damage in living organisms. The toxic effect of environmental pollutants is usually assessed on cell systems or in single species. We used the model organism Caenorhabditis elegans to compare the effect of synthetic PAHs with that of the EOM from environmental mixtures. The biological effect was measured by monitoring the expression level of some crucial genes, sensitive parameters of the organism's response. The results indicate the ability of C. elegans to counteract damage by mounting a stress-response only in the presence of EOM. On the other hand the exposure of C. elegans to a mixture of synthetic PAHs determines the silencing of the transcriptional machinery, thus preventing the synthesis of proteins that are important for both the damage repair mechanism and survival itself. The results strongly indicate that the study of environmental toxicant effects at the molecular level may provide information on their mechanism of action.
机译：摘要：已知多环芳烃（PAH）施加诱变和致癌作用。来自环境混合物的提取有机物（EOM）的研究表明了生物体细胞内损伤的几种机制。环境污染物的毒性效果通常在细胞系统或单一物种上进行评估。我们使用了模型生物体Caenorhabditis elegis，从环境混合物中比较了合成PAHS与EOM的影响。通过监测一些关键基因的表达水平，生物体的敏感参数来测量生物学效应。结果表明C.杆状杆虫的能力仅在EOM的存在下安装应力响应来抵消损坏。另一方面，C.杆杆线虫对合成PAH的混合物的曝光决定了转录机械的沉默，从而防止了对损伤修复机制和存活本身重要的蛋白质。结果强烈表明，对分子水平的环境毒性效应研究可以提供有关其作用机制的信息。

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