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首页> 外文期刊>Journal of applied toxicology >Cellular localization of uranium in the renal proximal tubules during acute renal uranium toxicity
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Cellular localization of uranium in the renal proximal tubules during acute renal uranium toxicity

机译：在急性肾铀毒性期间肾近端小管中铀的细胞定位

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Renal toxicity is a hallmark of uranium exposure, with uranium accumulating specifically in the S3 segment of the proximal tubules causing tubular damage. As the distribution, concentration and dynamics of accumulated uranium at the cellular level is not well understood, here, we report on high-resolution quantitative in situ measurements by high-energy synchrotron radiation X-ray fluorescence analysis in renal sections from a rat model of uranium-induced acute renal toxicity. One day after subcutaneous administration of uranium acetate to male Wistar rats at a dose of 0.5 mg uranium kg(-1) body weight, uranium concentration in the S3 segment of the proximal tubules was 64.9 18.2 mu g g(-1), sevenfold higher than the mean renal uranium concentration (9.7 +/- 2.4 mu g g(-1)). Uranium distributed into the epithelium of the S3 segment of the proximal tubules and highly concentrated uranium (50-fold above mean renal concentration) in micro-regions was found near the nuclei. These uranium levels were maintained up to 8 days post-administration, despite more rapid reductions in mean renal concentration. Two weeks after uranium administration, damaged areas were filled with regenerating tubules and morphological signs of tissue recovery, but areas of high uranium concentration (100-fold above mean renal concentration) were still found in the epithelium of regenerating tubules. These data indicate that site-specific accumulation of uranium in micro-regions of the S3 segment of the proximal tubules and retention of uranium in concentrated areas during recovery are characteristics of uranium behavior in the kidney. Copyright (c) 2015 John Wiley & Sons, Ltd.
机译：肾毒性是铀曝光的标志，铀累积，特别是在近端小管的S3段中引起管状损伤。作为在细胞水平的积累铀的分布，浓度和动态尚未得到很好的理解，这里我们报告了从大鼠模型的肾脏部分中的肾脏部分中的高能同步辐射X射线荧光分析的高分辨率定量。铀诱导的急性肾毒性。在皮下施用醋酸铀酸铵到雄性Wistar大鼠的一天以0.5mg铀kg（-1）体重，近端小管S3区段中的铀浓度为64.918.2μg（-1），七倍高于平均肾铀浓浓度（9.7 +/-2.4μg（-1））。在核附近发现分布到近端小管的S3段和高度浓缩的铀（50倍上方平均肾浓度上方的50倍）的上皮的铀。尽管在肾脏浓度的平均浓度更快地减少，但核算后这些铀水平长达8天。铀给药两周后，填充受损小管的受损区域和组织恢复的形态迹象，但在再生小管的上皮内仍然存在高铀浓度（均匀肾浓度上方的100倍）。这些数据表明，在近端小管的近端小管的S3区段的微区域中铀的特异性累积和在恢复期间浓缩区域的铀的保留是肾脏中铀行为的特征。版权所有（c）2015 John Wiley＆Sons，Ltd。

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