Hepatotoxicity mechanisms of isoniazid: A mini-review

Hassan Hozeifa M.; Guo Hong-li; Yousef Bashir A.; Zhang Luyong; Jiang Zhenzhou

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Hepatotoxicity mechanisms of isoniazid: A mini-review

机译：Isoniazid的肝毒性机制：迷你审查

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摘要

Isoniazid (INH) is an antituberculosis drug associated with idiosyncratic liver injury in susceptible patients. INH-induced hepatotoxicity remains a significant clinical problem, but the underlying mechanisms are still unclear, despite the growing evidence that INH and/or its major metabolite, hydrazine, play an important role in hepatotoxicity. Copyright (c) 2015 John Wiley & Sons, Ltd.

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来源
《Journal of applied toxicology》 |2015年第12期|共6页
作者
Hassan Hozeifa M.; Guo Hong-li; Yousef Bashir A.; Zhang Luyong; Jiang Zhenzhou;
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作者单位

China Pharmaceut Univ Jiangsu Key Lab Drug Screening Nanjing 210009 Jiangsu Peoples R China;

China Pharmaceut Univ Jiangsu Key Lab Drug Screening Nanjing 210009 Jiangsu Peoples R China;

China Pharmaceut Univ Jiangsu Key Lab Drug Screening Nanjing 210009 Jiangsu Peoples R China;

China Pharmaceut Univ Jiangsu Key Lab Drug Screening Nanjing 210009 Jiangsu Peoples R China;

China Pharmaceut Univ Jiangsu Key Lab Drug Screening Nanjing 210009 Jiangsu Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类毒物学（毒理学）;
关键词
isoniazid; hepatotoxicity mechanisms; CYP2E1;

机译：异烟肼;肝毒性机制;CYP2E1;

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专利

1. Hepatotoxicity mechanisms of isoniazid: A mini-review [J] . Hassan Hozeifa M., Guo Hong-li, Yousef Bashir A., Journal of applied toxicology . 2015,第11a12期

机译：异烟肼的肝毒性机制：综述
2. Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway [J] . Jia Zhi-li, Cen Juan, Wang Jia-bo, Chemosphere . 2019,第JULa期

机译：异烟肼诱导的斑马鱼幼虫肝毒性的机制：激活ROS介导的ERS，细胞凋亡和Nrf2途径。
3. Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway [J] . Jia Zhi-li, Cen Juan, Wang Jia-bo, Chemosphere . 2019,第Jula期

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4. Modeling Regulatory and Metabolic Mechanismas For Acetaminophen-Induced Hepatotoxicity [C] . Guzikowski, S.A., Ierapetritou, . 2006

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5. Mechanisms of Rifampicin-induced Hepatotoxicity in Pregnane X Receptor Humanized Mice [D] . Phillips, Paige. 2020

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6. Metabolomic Study to Determine the Mechanism Underlying the Effects of Sagittaria sagittifolia Polysaccharide on Isoniazid- and Rifampicin-Induced Hepatotoxicity in Mice [O] . Xiu-Hui Ke, Chun-Guo Wang, Wei-Zao Luo, 2018

机译：代谢组学研究以确定人参的多糖对异烟肼和利福平诱导的小鼠肝毒性作用的机制
7. Metabolomic Study to Determine the Mechanism Underlying the Effects of Sagittaria sagittifolia Polysaccharide on Isoniazid- and Rifampicin-Induced Hepatotoxicity in Mice [O] . Xiu-Hui Ke, Chun-Guo Wang, Wei-Zao Luo, 2018

机译：代谢组研究，确定射击梭菌多糖对小鼠异硝基和利福平诱导的肝毒性作用的机制

Hepatotoxicity mechanisms of isoniazid: A mini-review

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