Xanthohumol ameliorates 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin–induced cellular toxicity in cultured MC3T3‐E1 osteoblastic cells

Suh Kwang Sik; Choi Eun Mi; Kim Hyun‐Sook; Park So Young; Chin Sang Ouk; Rhee Sang Youl; Pak Youngmi Kim; Choe Wonchae; Ha Joohun; Chon Suk

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Xanthohumol ameliorates 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin–induced cellular toxicity in cultured MC3T3‐E1 osteoblastic cells

机译：Xanthohumol改善培养MC3T3-E1骨细胞细胞中的2,3,7,8-四氯二氯胺-P-二恶英诱导的细胞毒性

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Abstract 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) is an environmental contaminant. Xanthohumol is a prenylated flavonoid found in hops ( Humulus lupulus ) and beer. The aim of the current study was to explore the role of xanthohumol in modulating the toxicity of TCDD in MC3T3‐E1 osteoblastic cells. In cells treated with TCDD alone, intracellular Ca 2+ concentrations, mitochondrial membrane potential disruption, reactive oxygen species production, cardiolipin peroxidation, nitric oxide release and cytochrome P450 1A1 expression were significantly increased. TCDD treatment increased the mRNA levels of extracellular signal‐regulated kinase 1 and nuclear factor kappa B, and significantly decreased the level of protein kinase B (AKT) in MC3T3‐E1 osteoblastic cells. However, the presence of xanthohumol alleviated the pathological effects of TCDD. In addition, xanthohumol treatment significantly increased the expression of genes associated with osteoblast differentiation (alkaline phosphatase, osteocalcin, osteoprotegerin and osterix). We conclude that xanthohumol has a beneficial influence and may antagonize TCDD toxicity in osteoblastic cells.

机译：摘要2,3,7,8-四氯二苯并苯并二恶蛋白（TCDD）是一种环境污染物。 Xanthohumol是在啤酒花（Humulus Lupulus）和啤酒中发现的戊酰化黄酮类化合物。目前研究的目的是探讨Xanthohumol在MC3T3-E1骨细胞中调节TCDD的毒性的作用。在用TCDD单独处理的细胞中，细胞内Ca 2+浓度，线粒体膜势破坏，反应性氧物质生产，心脂过氧化，一氧化氮释放和细胞色素P450 1A1表达显着增加。 TCDD治疗增加了细胞外信号调节激酶1和核因子Kappa B的mRNA水平，并显着降低了MC3T3-E1骨细胞细胞中的蛋白激酶B（AKT）的水平。然而，Xanthohohumol的存在缓解了TCDD的病理作用。此外，Xanthohumol治疗显着增加了与成骨细胞分化（碱性磷酸酶，骨液，骨盆蛋白酶和Osterix相关的基因的表达。我们得出结论，Xanthohumol具有有益的影响，并且可以拮抗骨细胞中的TCDD毒性。

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来源
《Journal of applied toxicology》 |2018年第8期|共11页
作者
Suh Kwang Sik; Choi Eun Mi; Kim Hyun‐Sook; Park So Young; Chin Sang Ouk; Rhee Sang Youl; Pak Youngmi Kim; Choe Wonchae; Ha Joohun; Chon Suk;
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作者单位

Department of Endocrinology &

Metabolism School of MedicineKyung Hee UniversitySeoul 130‐702;

Department of Endocrinology &

Metabolism School of MedicineKyung Hee UniversitySeoul 130‐702;

Department of Biomedical Laboratory Science College of Health SciencesCheongju UniversityCheongju;

Department of Medicine Graduate SchoolKyung Hee UniversitySeoul 130‐702 Republic of Korea;

Department of Endocrinology &

Metabolism School of MedicineKyung Hee UniversitySeoul 130‐702;

Department of Endocrinology &

Metabolism School of MedicineKyung Hee UniversitySeoul 130‐702;

Department of PhysiologyKyung Hee University College of MedicineSeoul 130‐701 Republic of Korea;

Department of Biochemistry and Molecular BiologyMedical Research Center for Bioreaction to Reactive;

Department of Biochemistry and Molecular BiologyMedical Research Center for Bioreaction to Reactive;

Department of Endocrinology &

Metabolism School of MedicineKyung Hee UniversitySeoul 130‐702;

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正文语种 eng
中图分类毒物学（毒理学）;
关键词
2; 3; 7; 8‐tetrachlorodibenzo‐p‐dioxin; mitochondrial function; osteoblast; oxidative stress; xanthohumol;

机译：2;3;7;8-四屠二氯二苯甲苯-P-二恶英;线粒体功能;骨液细胞;氧化胁迫;xanthohumol;

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1. Xanthohumol ameliorates 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin–induced cellular toxicity in cultured MC3T3‐E1 osteoblastic cells [J] . Suh Kwang Sik, Choi Eun Mi, Kim Hyun‐Sook, Journal of applied toxicology . 2018,第7a8期

机译：Xanthohumol改善培养MC3T3-E1骨细胞细胞中的2,3,7,8-四氯二氯胺-P-二恶英诱导的细胞毒性
2. Actein alleviates 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated cellular dysfunction in osteoblastic MC3T3-E1 cells [J] . Eun Mi Choi, Kwang Sik Suh, Woon-Won Jung, Environmental toxicology . 2017,第11a12期

机译：肌动蛋白减轻成骨细胞MC3T3-E1细胞中2,3,7,8-四氯二苯并-p-二恶英介导的细胞功能障碍
3. Ameliorative effects of docosahexaenoic acid on the toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in cultured rat hepatocytes [J] . Turkez Hasan, Geyikoglu Fatime, Yousef Mokhtar I. Toxicology and Industrial Health . 2016,第6期

机译：二十二碳六烯酸对2,3,7,8-四氯二苯并-p-二恶英诱导的大鼠肝细胞毒性的改善作用
4. Induction of Growth Arrest and DNA Damage-Inducible Genes in Human Hepatoma HepG2 Cells by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) [C] . Yanqun Liu, Yikai Zhou Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009 . 2009

机译：2,3,7,8-四氯二苯并-p-二恶英（TCDD）在人肝癌HepG2细胞中诱导生长停滞和DNA损伤诱导基因
5. Mechanisms for 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated effects on CD40 ligand-induced activation and effector function of primary human and mouse B cells [D] . Lu, Haitian 2010

机译：2,3,7,8-四氯二苯并-p-二恶英介导的对CD40配体诱导的人和小鼠B细胞活化和效应子功能的作用机理
6. Ameliorative effect of supplementation with l-glutamine on oxidative stress DNA damage cell viability and hepatotoxicity induced by 2378-tetrachlorodibenzo-p-dioxin in rat hepatocyte cultures [O] . Hasan Turkez, Fatime Geyikoglu, Mokhtar I. Yousef, 2012

机译：补充谷氨酰胺对2378-四氯二苯并-p-二恶英诱导的大鼠肝细胞氧化应激DNA损伤细胞活力和肝毒性的改善作用
7. Ameliorative effect of supplementation with l-glutamine on oxidative stress, DNA damage, cell viability and hepatotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat hepatocyte cultures [O] . Hasan Turkez, Fatime Geyikoglu, Mokhtar I. Yousef, 2012

机译：用L-谷氨酰胺对大鼠肝细胞培养物中2,3,7,8-四氯二苯甲苯-P-二恶英诱导氧化应激，DNA损伤，细胞活力和肝毒素的改进效果
8. Toxicity of Perfluoro-N-Decanoic Acid and 2,3,7,8-Tetrachlorodibenzo-P-Dioxin in L5178Y Mouse Lymphoma Cells. [R] . Andersen, M. E., George, M. E., Rogers, A. M., 1983

机译：全氟-N-癸酸和2,3,7,8-四氯二苯并-p-二恶英对L5178Y小鼠淋巴瘤细胞的毒性。

Xanthohumol ameliorates 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin–induced cellular toxicity in cultured MC3T3‐E1 osteoblastic cells

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