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首页> 外文期刊>Journal of applied toxicology >Carcinogenicity of dermally administered 1,2-dihydro-2,2,4-trimethylquinoline monomer in F344 rats and B6C3F1 mice.
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Carcinogenicity of dermally administered 1,2-dihydro-2,2,4-trimethylquinoline monomer in F344 rats and B6C3F1 mice.

机译：F344大鼠和B6C3F1小鼠中皮肤施用1,2-二氢-2,2,4-三甲基喹啉单体的致癌性。

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1,2-Dihydro-2,2,4-trimethylquinoline (TMQ) was evaluated in a 2-year study in which groups of 60 male or female F344 rats received 0, 36 or 60 mg kg(-1) (0, 0.022, or 0.037 mg cm(-2)) and groups of 60 male or female B6C3F1 mice received 0, 3.6 or 10 mg kg(-1) (0, 0.00136, 0.00435 mg cm(-2)) in acetone by topical administration. Survival of all treated groups was comparable to survival of controls. Mean body weights of female rats were lower than those of controls throughout the study but mean body weights of male rats and male and female mice were comparable to the mean body weights of controls. No neoplasms of the skin were observed in any group of rats or mice. Acanthosis at the site of application was increased in male and female rats that received 60 or 100 mg kg(-1) and hyperkeratosis was increased in female rats that received 60 mg kg(-1). The incidences of renal tubule adenoma and renal tubule adenoma or carcinoma were increased significantly in the 60 and 100 mg kg(-1) groups of male rats. There were no neoplastic or non-neoplastic lesions in mice associated with exposure to 1,2-dihydro-2,2,4-trimethylquinoline. In a 1-year initiation-promotion study, groups of 30 female SENCAR mice received an initiating dose of 50 mg kg(-1) 1,2-dihydro-2,2,4-trimethylquinoline followed by promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA), or an initiating dose of 7,12-dimethylbenzanthracene (DMBA) followed by promotion with 5, 10 or 25 mg kg(-1) 1,2-dihydro-2,2,4-trimethylquinoline. Other groups served as initiator control, promoter control, vehicle control and positive control (DMBA initiation, TPA promotion). In this system, 1,2-dihydro-2,2,4-trimethylquinoline-initiated skin was not promoted by TPA, and DMBA-initiated skin was not promoted by 1,2-dihydro-2,2,4-trimethylquinoline.
机译：在2年的研究中评价了1,2-二氢-2,2,2,2,2,2,2,2,2,2,2,2,2,2,2,4-三甲基喹啉（TMQ），其中60只雄性或雌性F344大鼠的组66或60mg kg（-1）（0,0.022通过局部给药，或0.037mg cm（-2））和60个雄性或雌性B6C3F1小鼠的60只雄性或雌性B6C3F1小鼠（0,00136,0.1）（0,00.136,000435mg cm（-2））。所有治疗组的存活与对照的存活相当。雌性大鼠的平均体重低于整个研究的对照，但是雄性大鼠和雄性小鼠的平均体重与平均对照的平均体重相当。在任何组或小鼠中没有观察到皮肤的肿瘤。施用部位的刺突量在接受60或100mg kg（-1）的雄性和雌性大鼠中增加，在接受60mg kg（-1）的雌性大鼠中增加了高察觉病。肾小管腺瘤和肾小管腺瘤或癌癌或癌的发生率在60和100mg kg（-1）次雄性大鼠中显着增加。小鼠中没有肿瘤或非肿瘤病变与暴露于1,2-二氢-2,2,2,4-三甲基喹啉相关。在1年开始的促进研究中，30个雌性Sencar小鼠的组接受了50mg kg（-1）1,2-二氢-2,2,4-三甲基喹啉的起始剂量，然后用12-O-四癸酰卟啉键促进-13-乙酸酯（TPA），或者是7,12-二甲基苯并蒽（DMBA）的引发剂量，然后用5,10或25mg kg（-1）1,2-二氢-2,2,4-三甲基喹啉促进。其他组用作引发剂控制，启动子控制，车辆控制和阳性对照（DMBA发起，TPA促销）。在该系统中，TPA未促进1,2-二氢-2,2,2,4-三甲基喹啉引发的皮肤，并且通过1,2-二氢-2,2,4-三甲基喹啉不促进DMBA引发的皮肤。

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