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首页> 外文期刊>Journal of applied toxicology >Thirteen week toxicity study of dietary l l ‐tryptophan in rats with a recovery period of 5?weeks
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Thirteen week toxicity study of dietary l l ‐tryptophan in rats with a recovery period of 5?weeks

机译：13周毒性研究饮食L L L-Thyptophan在恢复期为5？周的大鼠

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摘要

Abstract Althoughl tryptophan is nutritionally important and widely used in medical applications, toxicity data for its oral administration are limited. The purpose of this study was to evaluate the potential toxicity of an experimental diet containing addedl tryptophan at doses of 0 (basal diet), 1.25%, 2.5% and 5.0% when administered to SpragueDawley rats for 13爓eeks. There were no toxicological changes in clinical signs, ophthalmology, urinalysis, hematology, necropsy, organ weight and histopathology between control rats and those fed additionall tryptophan. Body weight gain and food consumption significantly decreased throughout the administration period in males in the 2.5% group and in both sexes in the 5.0% group. At the end of the dosing period, decreases in water intake in males in the 5.0% group and in serum glucose in females in the 5.0% group were observed. The changes described above were considered toxicologically significant; however, they were not observed after a 5爓eek recovery period, suggesting reversibility. Consequently, the noobservedadverseeffect level ofl tryptophan in the present study was 1.25% for males and 2.5% for females (mean intake ofl tryptophan: 779爉g kg1 body weight day1 [males] and 1765爉g kg1 body weight day1 [females]). As the basal diet used in this study contained 0.27% of proteinaceousl tryptophan, the noobservedadverseeffect level of overalll tryptophan was 1.52% for males and 2.77% for females (mean intake of overalll tryptophan: 948爉g kg1 body weight day1 (males) and 1956爉g kg1 body weight day1 (females)). We conclude thatl tryptophan has a low toxicity profile in terms of human use.
机译：摘要虽然色氨酸是营养的重要性和广泛应用于医学应用，但其口头管理的毒性数据有限。本研究的目的是评估含有在0（基础饮食）的剂量的添加剂的实验饮食的潜在毒性，当施用13‰eeks时，在0（基础饮食），1.25％，2.5％和5.0％时，1.25％，2.5％和5.0％。对照大鼠和对照大鼠之间的临床症状，眼科，尿液分析，血液学，尸体，器官重量和组织病理学没有毒理学变化。在2.5％组和5.0％集团中的2.5％群体中，体重增加和食物消耗显着下降。在计量期结束时，观察到5.0％组中的雄性中的水摄入量减少，5.0％组中的女性中的血清葡萄糖。上述变化被认为是毒理学上的重要性;但是，在5‰的EEK恢复期之后没有观察到它们，表明可逆性。因此，目前研究中的OFOBServedAdefEffEFFEFEFFEFFEFEFEFEFEFEFEFEFEFEFEFEFEFEFEFEFEFER为男性的1.25％，女性为2.5％（平均摄入色氨酸：779爉GKG1体重第1天[雄性]和1765爉GKG1体重第1天[女性]。由于本研究中使用的基础饮食含有0.27％的蛋白质素色氨酸，因此男性的NoobservedAdeEffect水平为2.52％，女性为2.77％（平均摄入量的色氨酸：948爉GKG1体重第1天（男性）和1956年爉gkg1体重第1天（女性））。我们得出结论，在人类使用方面，色氨酸具有低毒性概况。

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