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首页> 外文期刊>Journal of applied toxicology >Early‐life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice
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Early‐life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice

机译：早期暴露于低水平的偏移患者在学习和记忆中发挥障碍，并对成年男性小鼠的神经元和胶质种群的影响产生障碍

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Abstract Permethrin, a pyrethroid chemical, is widely used as a pesticide because of its rapid insecticidal activity. Although permethrin is considered to exert very low toxicity in mammals, the effects of early, lowlevel, chronic exposure on the adult central nervous system are unclear. In this study, we investigated the effects of lowlevel, chronic permethrin exposure in early life on the brain functions of adult mice, using environmentally relevant concentrations. We exposed mice to the acceptable daily intake level of permethrin (0.3爌pm) in drinking water during the prenatal and postnatal periods. We then examined the effects on the central nervous system in adult male offspring. In the permethrin group, we detected behavior that displayed incomplete adaptation to a novel environment, as well as an impairment in learning and memory. In addition, immunohistochemical analysis revealed an increase in doublecortin (an immature neuron marker) positive cells in the hippocampal dentate gyrus in the permethrin exposure group compared with the control group. Additionally, in the permethrin exposure group there was a decrease in astrocyte number in the hilus of the dentate gyrus, and remaining astrocytes were often irregularly shaped. These results suggest that exposure to permethrin at low levels in early life affects the formation of the neural circuit base and behavior after maturation. Therefore, in the central nervous system of male mice, lowlevel, chronic permethrin exposure during the prenatal and postnatal periods has effects that were not expected based on the known effects of permethrin exposure in mature animals.
机译：摘要拟除虫菊酯，一种拟除虫菊酯，广泛用作农药，因为其杀虫剂的快速活性。虽然甲虫被认为在哺乳动物中施加非常低的毒性，但早期，较低，慢性暴露在成人中枢神经系统上的影响尚不清楚。在这项研究中，我们研究了利用环境相关浓度的成人小鼠脑功能的早期生命中较低寿命，慢性氯蛋白暴露的影响。在产前和产前期间，我们将小鼠暴露于饮用水中含水蛋白（0.3℃）的可接受的每日摄入水平。然后我们检查了成年男性后代中枢神经系统对中枢神经系统的影响。在Permethrin组中，我们检测到对新颖环境的不完全适应的行为，以及学习和记忆的损害。此外，与对照组相比，免疫组织化学分析显示在渗透素曝光组中的海马齿状齿状物中的双峰素（未成熟神经元标记）阳性细胞增加。另外，在渗透素曝光组中，在牙齿过滤的Hilus中，在牙齿过滤器中的数量减少，并且剩余的星形胶质细胞通常不规则地形状。这些结果表明，在早期寿命的低水平下暴露于氯菊酯会影响神经电路底座的形成和成熟后的行为。因此，在雄性小鼠的中枢神经系统中，产前和产后期间的慢性氯菊酯暴露在产前和产后期间具有未预期的效果，这些效果是基于成熟动物在成熟动物中的已知效果。

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