...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of applied toxicology >Comparison of the local pulmonary distribution of nanoparticles administered intratracheally to rats via gavage needle or microsprayer delivery devices
【24h】

Comparison of the local pulmonary distribution of nanoparticles administered intratracheally to rats via gavage needle or microsprayer delivery devices

机译：腹腔内施用腹腔内施用纳米颗粒的局部肺分布对大鼠通过饲养针或微喷雾剂输送装置进行比较

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Intratracheal administration methods are used to conduct toxicological assessments of inhaled nanoparticles (NPs), and gavage needles or microsprayers are common intratracheal delivery devices. The NP suspension is delivered in a liquid state via gavage needle and as a liquid aerosol via microsprayer. The differences in local pulmonary NP distribution (called the microdistribution) arising from the different states of the NP suspension cause differential pulmonary responses; however, this has yet to be investigated. Herein, using microbeam X-ray fluorescence microscopy, we quantitatively evaluated the TiO2 pulmonary microdistribution (per mesh: 100mx100m) in lung sections from rats administered an intratracheal dose of TiO2 NPs (6mgkg(-1)) via gavage needle or microsprayer. The results revealed that: (i) using a microsprayer appears to reduce the variations in TiO2 content (ng mesh(-1)) among rats (e.g., coefficients of variation, n=3, microsprayer vs gavage needle: 13% vs 30%, for the entire lungs); (ii) TiO2 appears to be deposited less in the right middle lobes than in the rest of the lung lobes, irrespective of the chosen intratracheal delivery device; and (iii) similar TiO2 contents (ng mesh(-1)) and frequencies are deposited in the lung lobes of rats administered TiO2 NPs via gavage needle or microsprayer. This suggests that the physical state of the administered NP suspension does not markedly alter TiO2 pulmonary microdistribution. The results of this investigation are important for the standardization of intratracheal administration methods. Copyright (c) 2016 John Wiley & Sons, Ltd.
机译：肿瘤内给药方法用于对吸入纳米颗粒（NPS）进行毒理学评估，并且饲养针或微果仁是常见的腹腔内输送装置。 NP悬浮液通过Gavage针在液态中递送，通过MicroPrayer作为液体气溶胶。来自NP悬浮液的不同状态产生的局部肺部NP分布（称为微分布）的差异导致差异肺反应;但是，这尚未调查。在此，使用Microbeam X射线荧光显微镜，我们定量评估来自大鼠的肺部的TiO2肺部微调（每种网状：100mx100m）通过饲养针或微壶饲喂肿瘤剂剂量的TiO2 NPS（6mgkg（-1））。结果表明：（i）使用微喷壶似乎减少大鼠中TiO2含量（Ng网状物（-1））的变化（例如，变异系数，n = 3，Microprayer与Gavage针：13％Vs 30％ ，整个肺部）; （ii）TiO2似乎在右中叶中沉积不如肺裂隙的其余叶片，而不管选择的腹腔内输送装置如何; （iii）类似的TiO 2内容物（Ng网状物（-1））和频率沉积在通过饲养针或微沼的大鼠施用TiO2 NP的大鼠肺裂片中。这表明施用的NP悬浮液的物理状态并不明显改变TiO2肺部微调。该调查的结果对于肿瘤内给药方法的标准化是重要的。版权所有（c）2016 John Wiley＆Sons，Ltd。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号