Modeling the impact of point mutations on the stability of proteins

Kulikov K. G.; Koshlan T. V

首页> 外文期刊>Journal of Bioinformatics and Computational Biology >Modeling the impact of point mutations on the stability of proteins

【24h】

Modeling the impact of point mutations on the stability of proteins

机译：模拟点突变对蛋白质稳定性的影响

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A new method has been introduced which allows us to determine the stability of protein complexes with point changes of amino acid residues that also take into account the three dimensional structure of the complex. This formulated and proven theorem is aimed at determining the criterion for the stability of protein molecules. The algorithm and software package were developed for analyzing protein interactions, taking into account their three-dimensional o structure from the PDB database.

机译：已经介绍了一种新方法，其允许我们确定蛋白质复合物的稳定性，氨基酸残基的点变化也考虑了复合物的三维结构。这种制定和经过验证的定理旨在确定蛋白质分子稳定性的标准。开发了算法和软件包，用于分析蛋白质相互作用，考虑到PDB数据库的三维O结构。

著录项

来源
《Journal of Bioinformatics and Computational Biology》 |2020年第4期|共16页
作者
Kulikov K. G.; Koshlan T. V;
展开▼
作者单位

Peter Great St Petersburg Polytech Univ Dept Med Phys St Petersburg 195251 Russia;

St Petersburg State Univ Dept Mol Biophys St Petersburg 199034 Russia;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
PDB database; condition number; entropy;

机译：PDB数据库;条件号;熵;

相似文献

外文文献
中文文献
专利

1. Modeling the impact of point mutations on the stability of proteins [J] . Kulikov K. G., Koshlan T. V Journal of Bioinformatics and Computational Biology . 2020,第4期

机译：模拟点突变对蛋白质稳定性的影响
2. Impacts of the charged residues mutation S48E/N62H on the thermostability and unfolding behavior of cold shock protein: insights from molecular dynamics simulation with Go model [J] . Su Ji-Guo, Han Xiao-Ming, Zhao Shu-Xin, Journal of molecular modeling . 2016,第4期

机译：带电残基突变S48E / N62H对冷休克蛋白的热稳定性和展开行为的影响：Go模型分子动力学模拟的启示
3. IMPACT OF POINT MUTATIONS AND AMINO ACID MODIFICATIONS ON THE STRUCTURE AND STABILITY OF PEPTIDES AND PROTEINS PROBED BY FT-IR SPECTROSCOPY [J] . Fabian H., Otvos L., Schultz C., Journal of Molecular Structure . 1995,第0期

机译：点突变和氨基酸修饰对FT-IR光谱法检测肽和蛋白质的结构和稳定性的影响
4. Impact of cystinosin mutations on protein stability by differential dynamic SILAC and protein network by differential interactomics [C] . N. Nevo, L. Thomas, C. Chhuon, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：差动副学通过鉴别动态硅酸和蛋白质网络对血液瘤蛋白突变对蛋白质稳定性的影响
5. Asymmetric Matching Allele Models: Imperfect Matching, Stability and the Impact of Mutation [D] . Williamson, Michael. 2018

机译：不对称匹配等位基因模型：突变匹配，稳定性和突变的影响
6. Computational Modeling of Structurally Conserved Cancer Mutations in the RET and MET Kinases: The Impact on Protein Structure Dynamics and Stability [O] . Anshuman Dixit, Ali Torkamani, Nicholas J. Schork, 2009

机译：RET和MET激酶中结构保守的癌症突变的计算模型：对蛋白质结构动力学和稳定性的影响
7. Computational Modeling of Structurally Conserved Cancer Mutations in the RET and MET Kinases: The Impact on Protein Structure, Dynamics, and Stability [O] . Dixit, Anshuman, Torkamani, Ali, Schork, Nicholas J., 2009

机译：RET和MET激酶中结构保守的癌症突变的计算模型：对蛋白质结构，动力学和稳定性的影响

Modeling the impact of point mutations on the stability of proteins

摘要

著录项

相似文献

相关主题

期刊订阅