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首页> 外文期刊>Journal of biochemical and molecular toxicology >The effect of N-acetylcysteine supplementation on the oxidative stress levels, apoptosis, DNA damage, and hematopoietic effect in pesticide-exposed fish blood
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The effect of N-acetylcysteine supplementation on the oxidative stress levels, apoptosis, DNA damage, and hematopoietic effect in pesticide-exposed fish blood

机译：N-乙酰半胱氨酸补充对农药暴露鱼类血液中氧化应激水平，凋亡，DNA损伤和造血作用的影响

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Cysteine is important for protein synthesis, detoxification, and diverse metabolic functions. However, cysteine metabolism has been poorly described in fish, and the role of the therapeutic effect in pesticide toxicology on aquatic organisms is unknown. The aim of this study was to determine the effects of regular cysteine treatment on the hematology, biochemistry, apoptosis, oxidative DNA damage, and antioxidant parameters in fish blood after chemical application. Therefore, fish were exposed to cypermethrin for 2 weeks. Then two different concentrations of N-acetylcysteine (NAC) were applied for a 4-day treatment period and compared with the group of the self-healing process. At the end of the treatment, the hematological index, blood biochemical parameters, paraoxonase (PON), arylesterase (ARE), and myeloperoxidase (MPO) activities in the fish blood samples were investigated. With regard to the hematological parameters, statistical differences were obtained except for mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) (P < 0.05). Enzyme activities (ARE, PON, and MPO), as well as some biochemical parameters (creatinin [Cre], alanine amino transferase, total glyceride, alkaline phosphatase, iron, calcium, low density lipoprotein-cholesterol [LDL-C], sodium, and potassium), were found to be importantly different among all groups at the P < 0.05 level, while 8-hydroxydeoxyguanosine and caspase-3 levels were determined to be high in the pesticide group but decreased significantly in NAC-treated groups (P < 0.05). According to the results of the study, acute cysteine treatment showed an ameliorative effect on the hematological index, biochemical parameters, PON, MPO, and ARE in the blood in the all the treatment group fish. The positive effect of NAC on protein synthesis, detoxification, and diverse metabolic functions against cypermethrin toxicity was more effective in 1.0mM NAC. NAC has an important therapeutic effect on pesticide-induced hematoxicity for fish in terms of all the data.
机译：半胱氨酸对于蛋白质合成，排毒和不同的代谢功能很重要。然而，半胱氨酸代谢在鱼类中赘言，并且治疗效果对水生生物体的毒物毒理学的作用是未知的。该研究的目的是确定化学应用后鱼血中常规半胱氨酸处理对血液学，生物化学，凋亡，氧化DNA损伤和抗氧化参数的影响。因此，将鱼暴露于氯氰菊酯2周。然后将两种不同浓度的N-乙酰半胱氨酸（NAC）施用于4天治疗期并与自我愈合过程组进行比较。在治疗结束时，研究了血液学指数，血液生化参数，定律酶（PON），芳基酯酶和鱼类样品中的髓氧化酶（MPO）活性。关于血液学参数，除了平均碎石血红蛋白（MCH）外，获得统计学差异，平均血管血红蛋白浓度（MCHC）（P <0.05）。酶活性（是，PON和MPO），以及一些生化参数（Creatinin [Cre]，丙氨酸氨基转移酶，总甘油酯，碱性磷酸酶，铁，钙，低密度脂蛋白 - 胆固醇[LDL-C]，钠，在P <0.05水平的所有组中发现，在所有基团中发现，在农药组中测定8-羟基氧基核苷酸和胱天冬酶-3水平，但在NAC处理组中显着下降（P <0.05 ）。根据该研究的结果，急性半胱氨酸治疗对血液学指数，生化参数，PON，MPO，并在所有治疗组鱼类中的血液中显示出改进效果。 NAC对蛋白质合成，解毒和不同代谢功能的阳性作用在1.0mm NaC中更有效。 NAC在所有数据方面对鱼类诱导的农药诱导的血质毒性具有重要的治疗效果。

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