Fisetin induces apoptosis in breast cancer MDA‐MB‐453 cells through degradation of HER2/neu and via the PI3K/Akt pathway

Guo Gang; Zhang Wenjie; Dang Minyan; Yan Mingzhu; Chen Zheng

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Fisetin induces apoptosis in breast cancer MDA‐MB‐453 cells through degradation of HER2/neu and via the PI3K/Akt pathway

机译：通过HER2 / NEU和PI3K / AKT途径诱导乳腺癌MDA-453细胞中的细胞凋亡诱导乳腺癌MDA-MB-453细胞凋亡

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Abstract Overexpression of human epidermal growth factor receptor 2 (HER2) is observed in breast cancer. The major snag?faced by the human population is the development of chemoresistance to HER2 inhibitors by advanced stage breast cancer cells. Moreover, recent researchers focussed on fisetin as an antiproliferative and chemotherapeutic agent. Therefore, this study was intended to analyze the effects of fisetin on HER2/neu‐overexpressing breast cancer cell lines. Our results depicted that fisetin induced apoptosis of these cells by various mechanisms, such as inactivation of the receptor, induction of proteasomal degradation, decreasing its half‐life, decreasing enolase phosphorylation, and alteration of phosphatidylinositol 3‐kinase/Akt signaling.

机译：摘要在乳腺癌中观察到人表皮生长因子受体2（HER2）的过度表达。主要的障碍是面对人口的是通过晚期乳腺癌细胞对HER2抑制剂的化学抑制剂的发展。此外，最近的研究人员侧重于Fisetin作为抗增殖和化学治疗剂。因此，该研究旨在分析Fisetin对HER2 / Neu过表达乳腺癌细胞系的影响。我们的结果表明，Fisetin通过各种机制诱导这些细胞的细胞凋亡，例如受体的灭活，诱导蛋白酶体降解，降低其半衰期，降低烯醇酶磷酸化，以及磷脂酰肌醇3-激酶/ AKT信号传导的改变。

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来源
《Journal of biochemical and molecular toxicology》 |2019年第4期|共7页
作者
Guo Gang; Zhang Wenjie; Dang Minyan; Yan Mingzhu; Chen Zheng;
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作者单位

Scientific Research Department Innoscience ResearchSelangor Malaysia;

Health Care Department for WomenNorthwest Women's and Children's HospitalXi'an China;

Scientific Research Department Innoscience ResearchSelangor Malaysia;

Department of NeurologyXijing Hospital Fourth Military Medical University (FMMU)Xi'an China;

Department of GalactophoreShandong Provincial Western HospitalJinan China;

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正文语种 eng
中图分类生物化学;
关键词
apoptosis; breast cancer; fisetin; human epidermal growth factor receptor 2/neu; phosphatidylinositol 3‐kinase/Akt;

机译：细胞凋亡;乳腺癌;Fisetin;人表皮生长因子受体2 / Neu;磷脂酰肌醇3-激酶/ akt;

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1. Fisetin induces apoptosis in breast cancer MDA‐MB‐453 cells through degradation of HER2/neu and via the PI3K/Akt pathway [J] . Guo Gang, Zhang Wenjie, Dang Minyan, Journal of biochemical and molecular toxicology . 2019,第4期

机译：通过HER2 / NEU和PI3K / AKT途径诱导乳腺癌MDA-453细胞中的细胞凋亡诱导乳腺癌MDA-MB-453细胞凋亡
2. UNBS5162 induces growth inhibition and apoptosis via inhibiting PI3K/AKT/mTOR pathway in triple negative breast cancer MDA-MB-231 cells [J] . Yue Xin, Li Mingzhong, Chen Dongxiang, Experimental and therapeutic medicine . 2018,第5期

机译：UNBS5162通过抑制三重阴性乳腺癌MDA-MB-231细胞中的PI3K / AKT / MTOR途径诱导生长抑制和细胞凋亡
3. Resveratrol Induces Apoptosis through PI3K/Akt and p53 Signal Pathway in MDA-MB-231 Breast Cancer Cells [J] . Jung-Ki Kwon, Young-Seok Park, Byung-Kwon Park, Korean Journal of Food Science and Technology . 2012,第4期

机译：白藜芦醇通过MDA-MB-231乳腺癌细胞中的PI3K / Akt和p53信号通路诱导凋亡。
4. M2-A, A Novel Amonafide Analogue, Induces Apoptosis and G2-M Arrest via Decreasing Topoisomerase LIa Activity and Inhibits PI3K/Akt Pathway on HL60 Cells [C] . The 12th Asian Pacific Confederation of Chemical Engineering Congress(第十二届亚太化工联盟大会暨化工展览会)论文集 . 2008

机译：M2-A，一种新颖的阿莫那肽类似物，通过降低拓扑异构酶LIa活性诱导HL60细胞凋亡和G2-M逮捕并抑制PI3K / Akt途径。
5. DLX4 homeoprotein promotes PI3K/Akt anti-apoptosis pathway in ER negative breast cancer cells through upregulation of VEGFA. [D] . Wu, Weiwei. 2010

机译：DLX4同源蛋白通过上调VEGFA促进ER阴性乳腺癌细胞中的PI3K / Akt抗凋亡途径。
6. CLE-10 from Carpesium abrotanoides L. Suppresses the Growth of Human Breast Cancer Cells (MDA-MB-231) In Vitro by Inducing Apoptosis and Pro-Death Autophagy Via the PI3K/Akt/mTOR Signaling Pathway [O] . Li Tian, Fan Cheng, Lei Wang, 2019

机译：拟南芥Carlosium Cle-10通过PI3K / Akt / mTOR信号通路诱导细胞凋亡和促死亡前自噬从而抑制人乳腺癌细胞（MDA-MB-231）的体外生长。
7. Degradation of HER2/neu by apigenin induces apoptosis through cytochrome c release and caspase-3 activation in HER2/neu-overexpressing breast cancer cells [O] . Way Tzong-Der, Kao Ming-Ching, Lin Jen-Kun 2005

机译：芹菜素对HER2 / neu的降解通过细胞色素c的释放和caspase-3激活诱导过表达HER2 / neu的乳腺癌细胞凋亡
8. Effects of Csk Homologous Kinase Overexpression on HER2/Neu-Mediated Signal Transduction Pathways in Breast Cancer Cells. [R] . Zagozdzon, R., Avraham, H. 2005

机译：Csk同源激酶过表达对乳腺癌细胞HER2 / Neu介导的信号转导通路的影响。

Fisetin induces apoptosis in breast cancer MDA‐MB‐453 cells through degradation of HER2/neu and via the PI3K/Akt pathway

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