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首页> 外文期刊>Journal of biochemical and molecular toxicology >Association of Lp‐PLA2 G994T gene polymorphism with risk of ischemic stroke in Chinese population
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Association of Lp‐PLA2 G994T gene polymorphism with risk of ischemic stroke in Chinese population

机译：LP-PLA2 G994T基因多态性与中国人口缺血性卒中风险的关联

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摘要

Abstract The association between lipoprotein‐associated phospholipase A2 (Lp‐PLA2) G994T gene polymorphism and the risk of ischemic stroke is unclear. The aim of this study is to investigate the influence of Lp‐PLA2 G994T genetic variant on the pathogenesis of ischemic stroke in Chinese population. A total of 348 patients with a clinical diagnosis of ischemic stroke and 260 gender‐matched control subjects under physical examination were recruited from hospitals and genotyped for G994T gene polymorphism. The results showed that there was a significant difference in the genotype distribution between the two groups and people with GT or TT genotype were associated with the higher risk of ischemic stroke even after adjusting the effects of potential confounding factors. In addition, both ischemic stroke patients and control subjects carrying T allele showed relatively lower Lp‐PLA2 activity and higher oxLDL level. Therefore, Lp‐PLA2 G994T gene polymorphism may be an independent risk factor of ischemic stroke in Chinese population.
机译：摘要脂蛋白相关的磷脂酶A2（LP-PLA2）G994T基因多态性和缺血性卒中风险的关联尚不清楚。本研究的目的是探讨LP-PLA2 G994T遗传变异对中国人群缺血性卒中发病机制的影响。共有348例患有缺血性卒中临床诊断的患者和260名性别匹配的对照受试者，并从医院招募了医院和G994T基因多态性的基因分型。结果表明，即使在调整潜在混淆因素的影响之后，两组和GT或TT基因型的基因型分布与GT或TT基因型之间的基因型分布也有显着差异。此外，缺血性卒中患者和携带的对照受试者携带T等位基因显示出相对较低的LP-PLA2活性和更高的耐氧基杆水平。因此，LP-PLA2 G994T基因多态性可能是中国人群中缺血性卒中的独立危险因素。

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  • 作者

    Ni Jing; Gu Hong; Hu Wuhao; Zhou Fang; Zhu Xue; Wang Ke;

  • 作者单位

    Department of Geriatric RehabilitationJiangsu Rongjun HospitalWuxi 214035 Jiangsu Province People's;

    Department of Geriatric RehabilitationJiangsu Rongjun HospitalWuxi 214035 Jiangsu Province People's;

    Department of Geriatric RehabilitationJiangsu Rongjun HospitalWuxi 214035 Jiangsu Province People's;

    Department of Geriatric RehabilitationJiangsu Rongjun HospitalWuxi 214035 Jiangsu Province People's;

    Key Laboratory of Nuclear Medicine Ministry of Health Jiangsu Key Laboratory of Molecular Nuclear;

    Key Laboratory of Nuclear Medicine Ministry of Health Jiangsu Key Laboratory of Molecular Nuclear;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    gene polymorphism; ischemic stroke; Lp‐PLA2;

    机译：基因多态性;缺血性卒中;LP-PLA2;

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