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首页> 外文期刊>Journal of biochemical and molecular toxicology >Ameliorative effect of nanoencapsulated flavonoid against chlorpyrifos‐induced hepatic oxidative damage and immunotoxicity in Wistar rats
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Ameliorative effect of nanoencapsulated flavonoid against chlorpyrifos‐induced hepatic oxidative damage and immunotoxicity in Wistar rats

机译：纳米封装黄酮对Wistar大鼠免疫氧化损伤和免疫毒性的改进作用

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Abstract The theme of the present work is to evaluate the protective effect of nanoencapsulated quercetin (NEQ) against chlorpyrifos (CPF)‐induced hepatic damage and immune alterations in animals. Nanoparticles (NP) drug encapsulation was prepared. Forty male Wistar rats were divided into eight groups. Two groups served as control and CPF (13.5?mg/kg) treatment for 28 days. Other three groups were free quercetin (QC), NP and NEQ treated with 3 mg/kg respectively for 15 days; whereas remaining three groups received treatment of CPF and QC, NP, NEQ, respectively, for 15 days. The results show that significantly altered oxidative stress in the liver tissue and liver enzyme parameters in blood and immune responses in CPF‐treated rats compared to controls. Administration of NEQ attenuated biochemical and immunological parameters. The liver histopathological analysis confirmed pathological improvement. Hence, use of NEQ appeared to be beneficial to a great extent in attenuating and restoring hepatic oxidative damage and immune alteration sustained by pesticide exposure.
机译：摘要本作本作的主题是评估纳米封装槲皮素（NEQ）对紫外（CPF）的保护作用 - 诱导动物的肝损伤和免疫改变。制备纳米颗粒（NP）药物包封。四十只男性Wistar大鼠分为八组。两组用于控制和CPF（13.5×mg / kg）治疗28天。其他三组是自由槲皮素（QC），NP和NEQ分别用3mg / kg处理15天;然而，剩下三组接受了分别治疗CPF和QC，NP，NEQ，15天。结果表明，与对照相比，CPF处理大鼠血液和免疫应答中的肝组织和肝脏酶参数显着改变了氧化应激。 NEQ减毒生物化学和免疫学参数管理。肝脏组织病理学分析证实了病理改善。因此，使用NEQ似乎在很大程度上有益，在很大程度上衰减和恢复农药暴露的肝氧化损伤和免疫改变。

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