Taurine abrogates mammary carcinogenesis through induction of apoptosis in Sprague‐Dawley rats

Vanitha Manickam Kalappan; Anandakumar Pandi; Sakthisekaran Dhanapal

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Taurine abrogates mammary carcinogenesis through induction of apoptosis in Sprague‐Dawley rats

机译：牛磺酸通过诱导Sprague-Dawley大鼠的凋亡诱导乳腺发生

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Abstract Breast cancer is one of the most severe problems in oncology. Taurine is a sulfur‐containing amino acid with vital biological functions. The current study was intended to investigate the abnormalities in the expression of apoptosis‐associated proteins that lead to the progression of 7,12‐dimethyl benz[ a ]anthracene (DMBA)–induced breast cancer and to expose the protective effect of taurine on it. Rats were induced with DMBA by gastric intubation to induce breast cancer. Breast cancer–bearing animals were posttreated with taurine. The breast tumors induced by DMBA, analyzed in the current study, were characterized by increased protein/DNA expression of Bcl‐2 associated with downregulation in the expression of p53, Bax, and caspases. Taurine treatment reverted all the above changes induced by DMBA and inhibited the development of rat breast carcinoma through its ability to induce apoptosis.

机译：摘要乳腺癌是肿瘤中最严重的问题之一。牛磺酸是一种含硫氨基酸，具有重要的生物功能。目前的研究旨在探讨凋亡相关蛋白表达的异常，导致7,12-二甲基苯苯苯（DMBA）诱导的乳腺癌的进展，并暴露牛磺酸对其的保护作用。通过胃插管用DMBA诱导大鼠以诱导乳腺癌。乳腺癌的动物用牛磺酸进行后处理。在目前的研究中分析DMBA诱导的乳腺肿瘤，其特征在于将BCL-2的蛋白质/ DNA表达增加，与下调的P53，BAX和Caspases的表达相关。牛磺酸治疗恢复了DMBA诱导的所有上述变化，并通过其诱导细胞凋亡的能力抑制大鼠乳腺癌的发育。

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《Journal of biochemical and molecular toxicology》 |2018年第10期|共8页
作者
Vanitha Manickam Kalappan; Anandakumar Pandi; Sakthisekaran Dhanapal;
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作者单位

Department of Medical BiochemistryDr. ALM PGIBMS University of Madras Taramani CampusChennai India;

Department of Biomedical SciencesCollege of Health Sciences Arsi UniversityAsella Ethiopia;

Department of Medical BiochemistryDr. ALM PGIBMS University of Madras Taramani CampusChennai India;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
apoptotic regulators; breast cancer; 7; 12‐dimethyl benz a anthracene; taurine;

机译：细胞凋亡调节剂;乳腺癌;7;12-二甲基苯并[a]蒽;牛磺酸;

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1. Taurine abrogates mammary carcinogenesis through induction of apoptosis in Sprague‐Dawley rats [J] . Vanitha Manickam Kalappan, Anandakumar Pandi, Sakthisekaran Dhanapal Journal of biochemical and molecular toxicology . 2018,第10期

机译：牛磺酸通过诱导Sprague-Dawley大鼠的凋亡诱导乳腺发生
2. beta-Ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague-Dawley rat. [J] . Liu JR, Sun XR, Dong HW, International Journal of Cancer =: Journal International du Cancer . 2008,第12期

机译：β-紫罗兰酮可抑制Sprague-Dawley大鼠的乳腺癌变，增殖活性并诱导其凋亡。
3. Induction of apoptosis and downregulation of ER alpha in DMBA-induced mammary gland tumors in Sprague-Dawley rats by synthetic 3,5-disubstituted isoxazole derivatives [J] . Ananda Hanumappa, Kumar Kothanahally S. Sharath, Hegde Mahesh, Molecular and Cellular Biochemistry: An International Journal for Chemical Biology . 2016,第1a2期

机译：合成的3,5-二取代异恶唑衍生物诱导Sprague-Dawley大鼠DMBA诱导的乳腺肿瘤凋亡和ERα的下调
4. Blood chemistry profiles of DMBA-induced mammary tumor in female Sprague Dawley rats [C] . Padlianah, Mutmainnah Arif, Ika Yustisia International Conference on Bioinformatics and Nanomedicine from Natural Resources for Biomedical Research . 2019

机译：DMBA诱导的乳腺肿瘤血型乳腺肿瘤血型术治疗
5. Evaluation of the role of oxidative stress, inflammation and apoptosis in the pulmonary and the hepatic toxicity induced by cerium oxide nanoparticles following intratracheal instillation in male Sprague-Dawley rats [D] . Nalabotu, Siva Krishna 2012

机译：评价氧化应激，炎症和细胞凋亡在雄性Sprague-Dawley大鼠气管内滴注后氧化铈纳米颗粒诱发的肺部毒性和肝毒性中的作用
6. The effect of physical training on the N-methyl-N-nitrosourea-induced mammary carcinogenesis of Sprague–Dawley rats [O] . Iwona Malicka, Katarzyna Siewierska, Bartosz Pula, 2015

机译：体育锻炼对N-甲基-N-亚硝基脲诱导的Sprague-Dawley大鼠乳腺癌变的影响
7. β-ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague-Dawley rat [O] . Liu JR, Sun XR, Dong HW, 2008

机译：β-紫罗兰酮抑制sprague-Dawley大鼠乳腺的乳腺癌发生，增殖活性和诱导细胞凋亡
8. NTP Technical Report on the Toxicology and Carcinogenesis Studies of 3,3',4,4'-Tetrachloroazobenzene (TCAB) (CAS NO. 14047-09-7) in Harland Sprague-Dawley Rats and B6C3F1 Mice (Gavage Studies) [R] . 2010

机译：NTp关于3,3'，4,4'-四氯偶氮苯（TCaB）（Cas NO.14047-09-7）在Harland sprague-Dawley大鼠和B6C3F1小鼠中的毒理学和癌变研究的技术报告（灌胃研究）

Taurine abrogates mammary carcinogenesis through induction of apoptosis in Sprague‐Dawley rats

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