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首页> 外文期刊>Journal of biochemical and molecular toxicology >In vitro and in vivo effects of iron on the expression and activity of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase in rat spleen
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In vitro and in vivo effects of iron on the expression and activity of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase in rat spleen

机译：在体外和体内铁对葡萄糖6-磷酸脱氢酶，6-磷葡萄糖脱氢酶的表达和活性，以及大鼠脾脏的谷胱甘肽还原酶

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摘要

Iron is an indispensable element for vital activities in almost all living organisms. It is also a cofactor for many proteins, enzymes, and other essential complex biochemical processes. Therefore, iron trafficking is firmly regulated by Hepcidin (Hamp), which is regarded as the marker for iron accumulation. The disruption of iron homeostasis leads to oxidative stress that causes various human diseases, but this mechanism is still unclear. The aim of this study is to provide a better in vivo and in vitro understanding of how long-term iron overload affects the gene expression and activities of some antioxidant enzymes, such as glucose 6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), and glutathione reductase (GR) in the spleen. The findings of this study show that iron overload reduces the gene expression of G6pd, 6pgd, and Gr, but its actual effect was on the protein level.
机译：铁是几乎所有生物体中生命活动的不可或缺的元素。 它也是许多蛋白质，酶和其他必需的复杂生物化学过程的辅助因子。 因此，铁贩运牢固地由肝素（HAMP）牢固调节，其被认为是铁积累的标志物。 铁稳态破坏导致氧化应激导致各种人类疾病，但这种机制仍然尚不清楚。 本研究的目的是提供更好的体内和体外理解长期铁过载如何影响一些抗氧化酶的基因表达和活性，例如葡萄糖6-磷酸脱氢酶（G6PD），6-磷酸葡糖苷脱氢酶（ 6PGD）和脾脏中的谷胱甘肽还原酶（GR）。 本研究的结果表明，铁过载降低了G6PD，6PGD和GR的基因表达，但其实际效果是对蛋白质水平的。

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