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首页> 外文期刊>Journal of biochemical and molecular toxicology >Evaluation of the renoprotective effect of nano turmeric against toxic dose of copper sulfate: Role of vascular cell adhesion molecule-1, kidney injury molecule-1, and signal transducer and activator of transcription 3 protein expressions
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Evaluation of the renoprotective effect of nano turmeric against toxic dose of copper sulfate: Role of vascular cell adhesion molecule-1, kidney injury molecule-1, and signal transducer and activator of transcription 3 protein expressions

机译：纳米姜黄对硫酸盐毒性剂量的重新调节作用：血管细胞粘附分子-1，肾损伤分子-1和信号传感器和转录3蛋白表达活化剂的作用

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The aim of this study was to compare the potential renoprotective effects of turmeric (TM) and nano turmeric (NTM) with those of desferrioxamine (DSM) against copper sulfate (CS)-induced toxicity. Rats were administered a toxic dose of CS with TM, NTM, and DSM for 1 week. Next, serum-urea creatinine, uric acid, interleukin (IL)-10, c-reactive protein (CRP), and caspase-3 levels; renal nitric oxide (NO), glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), vascular cell adhesion molecule-1 (VCAM-1), kidney injury molecule (KIM)-1, signal transducer and activator of transcription 3 (STAT-3) protein expression; and nuclear factor (NF)-kappa B and B-cell lymphoma -2 (Bcl-2) messenger RNA expression levels were estimated. Administration of the investigated antioxidants downregulated the marked increase in urea, creatinine, uric acid, CRP, caspase-3, NO, MDA, VCAM-1, kidney injury molecule (KIM-1), STAT-3, NF-kappa B, and DNA fragmentation, and increased Bcl-2, IL-10, GSH, and SOD levels induced by CS. The histopathological examination confirmed the effects of the antioxidants on the investigated biochemical parameters. Interestingly, NTM exhibited a superior renoprotective effect, which was comparable with that of DSM. In conclusion, NTM was shown to be a promising candidate against CS-induced toxicity, and several molecular mechanisms were implicated in the CS-induced renotoxicity as well as the treatment effects of NTM.
机译：本研究的目的是将姜黄（TM）和纳米姜黄（NTM）与硫酸铜（CS）致氧氧杂种（DSM）的潜在对姜黄（DSM）的潜在再试反对作用进行比较。将大鼠用TM，NTM和DSM施用毒性剂量的CS，1周。接下来，血清尿素肌酐，尿酸，白细胞介素（IL）-10，C-反应蛋白（CRP）和Caspase-3水平;肾脏一氧化氮（NO），谷胱甘肽（GSH），丙二醛（MDA），超氧化物歧化酶（SOD），血管细胞粘附分子-1（VCAM-1），肾损伤分子（KIM）-1，信号传感器和转录的活化剂3（STAT-3）蛋白表达;估计核因子（NF）-Kappa B和B细胞淋巴瘤-2（Bcl-2）信使RNA表达水平。调查的抗氧化剂的给药下调了尿素，肌酐，尿酸，CRP，Caspase-3，NO，MDA，VCAM-1，肾损伤分子（Kim-1），Stat-3，NF-Kappa B和DNA碎片，和Cs诱导的Bcl-2，IL-10，GSH和SOD水平增加。组织病理学检查证实了抗氧化剂对研究生化参数的影响。有趣的是，NTM表现出优异的renophotective效果，与DSM的效果相当。总之，NTM被证明是针对CS诱导的毒性的有希望的候选者，并且在CS诱导的肾谐毒性以及NTM的治疗效果中涉及几种分子机制。

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