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首页> 外文期刊>Journal of biomaterials applications >Evaluation of comparative soft tissue response to bone void fillers with antibiotics in a rabbit intramuscular model
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Evaluation of comparative soft tissue response to bone void fillers with antibiotics in a rabbit intramuscular model

机译：兔肌内模型抗生素对比较软组织响应对比较软组织响应的评价

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摘要

Management of osseous and soft tissue dead space can be a significant challenge in the clinical setting. Calcium sulphate and calcium phosphate-based biomaterials are increasingly being used as alternatives to PMMA for local release of antibiotics, in particular to fill dead space following surgical debridement. This study aims to observe the in-vivo absorption characteristics and tissue response of three commercially available calcium sulphate-based materials combined with gentamicin in an established soft tissue rabbit model. The implant materials (1cc) were placed into four intramuscular sites in 18 New Zealand White rabbits (n = 6). In-life blood samples and radiographs were taken from each animal following implantation. Animals were sacrificed at 0, 1, 7, 21, 42 and 63 days post-operatively (n = 3) and implant sites analysed by micro-computed tomography and histology. Radiographically and histologically, recrystallized calcium sulphate (RCS) absorbed the fastest with complete absorption by day 21. Calcium sulphate/HA composite (CSHA) and Calcium sulphate/calcium carbonate (CSCC) absorbed slower and were detectable at day 63. Residual bead analysis revealed the presence of detectable gentamicin at 24 h and 7 days for CSHA and RCS but none in CSCC. Systemic levels of gentamicin were only detected between 1 h and 24 h. Serological inflammatory cytokine expression for IL-6, TNF-alpha and IL-1 beta indicated no unusual inflammatory response to the implanted materials. Calcium sulphate materials loaded with gentamicin are effective in resolving a surgically created dead space without eliciting any adverse host response.
机译：综述和软组织死区的管理可能是临床环境中的重大挑战。硫酸钙和基于磷酸钙的生物材料越来越多地被用作PMMA的替代品，以局部释放抗生素，特别是填充外科清新后的死亡空间。本研究旨在观察三种市售硫酸钙基材料的体内吸收特性和组织响应，这些基于硫酸钙基材料结合庆大霉素在建立的软组织兔模型中。将植入物材料（1cc）置于18个新西兰白兔（n = 6）中的四个肌内位点。植入后的每只动物都取自生命中的血液样本和射线照片。可操作地（n = 3）和通过微型计算机断层扫描和组织学分析的植入部位处处于0,1,7,21,42和63天处处死动物。结晶硫酸钙（RCS）被吸收的结晶硫酸钙（RCS）吸收最快的21天。硫酸钙/ HA复合（CSHA）和硫酸钙/碳酸钙（CSCC）吸收较慢，并在第63天中检测到。残留珠子分析显示在24小时和7天的CSHA和RCS的存在，但在CSCC中没有任何可检测的庆大霉素。仅在1小时和24小时之间检测到全身水平的庆大霉素。 IL-6，TNF-α和IL-1β的血清炎症细胞因子表达表明对植入材料没有异常的炎症反应。硫酸钙材料含有庆大霉素的硫酸钙材料可有效地解析手术产生的死区，而不引出任何不利宿主响应。

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