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首页> 外文期刊>AIChE Journal >Blend Uniformity and Powder Phenomena Inside the Continuous Tumble Mixer Using DEM Simulations
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Blend Uniformity and Powder Phenomena Inside the Continuous Tumble Mixer Using DEM Simulations

机译：使用DEM模拟在连续式滚筒混合机中混合均匀性和粉末现象

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Powder mixing is an essential operation in pharmaceutical, food, and petrochemical industries. Pharmaceutical companies have been working in the implementation of continuous processes as an alternative to the batch process using the food and drug administration process analytical technology initiative. The main goal was to understand the mixing phenomena inside the continuous tumble mixer and monitor blend uniformity using discrete element method. Results demonstrated that the main mixing mechanism is convection similar to the common tumbling mixers. This mechanism is driven by the bulk flow of the particles, due to the mixer rotation. The simulations' results, demonstrated that the cohesion reduces the concentration variability due to the higher holdup, particle interactions, and mean residence time. The blend uniformity at the exit of the system was measured and a relationship between relative standard distribution, cohesion, and the collision frequency was found. (c) 2014 American Institute of Chemical Engineers AIChE J, 61: 792-801, 2015
机译：粉末混合是制药，食品和石化行业中必不可少的操作。制药公司一直在努力实施连续过程，以替代使用食品和药物管理过程分析技术的分批过程。主要目的是了解连续式滚筒混合机内部的混合现象，并使用离散元方法监控混合均匀性。结果表明，主要的混合机理是对流，类似于普通的翻滚混合器。由于混合器旋转，这种机制由颗粒的大量流动驱动。模拟结果表明，由于较高的滞留率，颗粒相互作用和平均停留时间，内聚力降低了浓度变化。测量系统出口处的共混物均匀性，并发现相对标准分布，内聚力和碰撞频率之间的关系。 （c）2014美国化学工程师学会AIChE J，61：792-801，2015

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