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Multiphase transport modeling for vacuum drying of pharmaceutical products

机译：药品真空干燥的多相传输建模

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Vacuum drying of active pharmaceutical ingredients (API) is an energy-intensive process that is often a manufacturing bottleneck. A multiphase transport model to predict drying performance under the assumption that boiling is the dominant mechanism is developed. Laboratory scale drying experiments were performed over a range of temperatures and pressures using acetone as the solvent and glass beads of three different particle sizes to mimic APIs. A two-phase transport model with the vapor and solid considered as one phase and the liquid treated as the second phase was capable of qualitatively reproducing the drying dynamics is found. Adjustable model parameters estimated from experimental data collected over a range of operating conditions exhibited trends that provided further insight into drying behavior. Boiling is the dominant mechanism in vacuum drying and our transport model captured the key physics of the process. (c) 2015 American Institute of Chemical Engineers
机译：活性药物成分（API）的真空干燥是一个能源密集型过程，通常是制造瓶颈。在沸腾是主要机理的假设下，开发了一种多相传输模型来预测干燥性能。使用丙酮作为溶剂并使用三种不同粒径的玻璃珠模拟API，在一定温度和压力范围内进行了实验室规模的干燥实验。发现了一个两相输运模型，其中蒸气和固体被视为一相，而液体被视为第二相则能够定性地再现干燥动力学。根据在一系列操作条件下收集的实验数据估算出的可调模型参数显示出趋势，可进一步了解干燥行为。沸腾是真空干燥的主要机理，我们的运输模型捕捉了该过程的关键物理原理。 （c）2015美国化学工程师学会

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