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首页> 外文期刊>AIChE Journal >Drug Release Kinetics and Mechanism from PLGA Formulations
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Drug Release Kinetics and Mechanism from PLGA Formulations

机译：PLGA制剂的药物释放动力学和机理

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The release kinetics of indomethacin (IND) and hydrochlorothiazide (HCT) from drug/PLGA formulations with different copolymer composition and molecular weight of PLGA were measured in vitro by using a rotating disk system (USP II). The release mechanism of IND and HCT from their PLGA formulations was analyzed using a chemical-potential-gradient model combined with the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT). Furthermore, the release kinetics of IND and HCT from the PLGA formulations with different copolymer composition and molecular weight of PLGA were correlated and predicted in good accordance with the experimental data. It was found that the chemical-potential-gradient model combined with the PC-SAFT helped to understand the drug release mechanism from the drug/PLGA formulations. It also well correlated and predicted the drug release kinetics as function of copolymer composition and molecular weight of PLGA as well as of drug type. It helps to save time and costs for determination of the long-term drug release kinetics, especially for sustained drug release as obtained from the drug/PLGA formulations in this work. (c) 2016 American Institute of Chemical Engineers AIChE J, 62: 4055-4065, 2016
机译：使用旋转盘系统（USP II）在体外测量了具有不同共聚物组成和PLGA分子量的药物/ PLGA制剂中吲哚美辛（IND）和氢氯噻嗪（HCT）的释放动力学。使用化学势梯度模型结合扰动链统计缔合流体理论（PC-SAFT）分析了IND和HCT从PLGA制剂中的释放机理。此外，从共聚物数据和PLGA分子量不同的PLGA配方中，IND和HCT的释放动力学相互关联并得到了很好的预测。发现化学势梯度模型与PC-SAFT相结合有助于了解药物/ PLGA制剂的药物释放机理。它还很好地关联并预测了药物释放动力学与共聚物组成，PLGA分子量以及药物类型的关系。它有助于节省确定长期药物释放动力学的时间和成本，尤其是从这项工作中从药物/ PLGA制剂获得的持续药物释放时。 （c）2016美国化学工程师学会AIChE J，62：4055-4065，2016

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