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首页> 外文期刊>Journal of bodywork and movement therapies >Predictive models of six-minute walking distance in adults with sickle cell anemia: Implications for rehabilitation
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Predictive models of six-minute walking distance in adults with sickle cell anemia: Implications for rehabilitation

机译：镰状细胞贫血成人六分钟步行距离的预测模型：康复的含义

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Background: Sickle cell anemia (SCA) is characterized by a broad spectrum of abnormalities that affect most body organs and systems. To date, there is few data on the influence of these patients' clinical characteristics on the functional exercise capacity. Aim: To investigate the effect of the clinical complications on the functional exercise capacity of adult SCA patients. Method: Cross-sectional study, where 45 SCA patients underwent clinical evaluations, echocardi-ography, pulmonary function testing, and determination of six-minute walking distance (6MWD). Results: A significant correlation (P < 0.001) was found between 6MWD and hemoglobin (Hb) level, tricuspid regurgitation velocity, forced vital capacity, acute chest syndrome, and diffusing capacity for carbon monoxide. The prediction model for 6MWD explained 67% of the 6MWD variability (P< 0.001). Conclusions: Hemodynamics, cardiovascular function, pulmonary function, and episodes of acute lung injury seem to impact the 6MWD in adults with SCA.
机译：背景：镰状细胞贫血（SCA）的特征是影响大多数身体器官和系统的广谱异常。迄今为止，关于这些患者临床特征对功能锻炼能力的影响很少的数据。目的：探讨临床并发症对成人SCA患者功能运动能力的影响。方法：横截面研究，其中45名SCA患者接受了临床评估，超声病变，肺功能检测和六分钟步行距离（6MWD）的测定。结果：在6MWD和血红蛋白（HB）水平之间，三尖瓣流动速度，强制胸膜综合征，急性胸综合征，急性胸综合征，急性胸部综合征和一氧化碳扩散能力之间存在显着的相关性（P <0.001）。 6MWD的预测模型解释了6MWD变异性的67％（P <0.001）。结论：血流动力学，心血管功能，肺功能和急性肺损损伤的发作似乎对SCA的成年人影响了6MWD。

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