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Implications of rectal preconditioning for interpretation of sensory-motor data

机译：直肠预处理对感觉 - 电机数据解释的影响

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Testing of biomechanical properties of intestine requires the tissue to be preconditioned by applying cyclic loading to obtain repeatable mechanical data. However, little is known about the mechanosensory properties during intestinal preconditioning. We aimed to study the relationship between mechanical preconditioning of the human rectum and sensory response. Three fast rectal bag distensions to the pain threshold were done in seven healthy females. A visual analog scale (VAS) was used for sensory assessment. At each distension, we determined (1) time, bag cross-sectional area (CSA), radius (r), r/r(0), pressure and tension to reach VAS = 1, 3 and 5 (pain threshold); (2) the same parameters at induced contraction start; (3) CSA where the pressure started to increase (CSA(P>baseline)) and (4) the number of contractions. The time, CSA, r/r(0) and tension to reach VAS = 1 and VAS = 3 increased from distension 1 to 3 (4.9 P > 0.007), primarily due to difference between the first and second distension. For VAS = 5, r/r(0) was smaller in distension 3 than distension 1 (P 0.5). Compared with distension 1, CSA, r/r(0) and tension at contraction start, and CSA(P>baseline) were bigger in distensions 2 and 3 (5.5 P > 0.009). The pressure to reach the VAS levels, the contraction numbers and pressure at contraction start did not differ among distensions (P > 0.6). During mechanical preconditioning, CSA, tension and deformation increased at sub-pain levels, reflecting sensory adaptation. The data point to acute remodeling of a strain-dependent mechanism in the rectal wall. (C) 2019 Elsevier Ltd. All rights reserved.
机译：通过施加循环载荷来获得可重复的机械数据，肠的生物力学性能测试需要预处理组织。然而，关于肠道预处理期间的机械感性特性很少。我们旨在研究人体直肠和感官反应的机械预处理之间的关系。在七个健康的女性中完成了三个快速直肠袋对疼痛阈值的延伸。视觉模拟量表（VAS）用于感官评估。在每个光泽时，我们确定（1）时间，袋子横截面积（CSA），半径（R），R / R（0），压力和张力到达VAs = 1,3和5（疼痛阈值）; （2）诱导收缩开始的相同参数; （3）CSA，其中压力开始增加（CSA（P>基线））和（4）收缩次数。到达VAs = 1和VAs = 3的时间，CSA，R / R（0）和张力从扩散1至3（4.9p> 0.007）增加，主要是由于第一和第二扩散之间的差异。对于VAs = 5，r / r（0）在距离3的距离3中较小，距离1（p 0.5）。与距离1，CSA，R / R（0）和收缩开始时的张力相比，CSA（P>基线）在延伸2和3的越大越大（5.5 p> 0.009）。达到VAS级别的压力，收缩开始时的收缩数和压力在延迟中没有差异（p> 0.6）。在机械预处理期间，CSA，张力和变形在亚疼痛水平上增加，反映了感觉适应。数据点以急性重塑在直肠壁中的应变依赖机构。 （c）2019年elestvier有限公司保留所有权利。

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