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首页> 外文期刊>Journal of Biomechanics >Inter-species investigation of the mechano-regulation of bone healing: comparison of secondary bone healing in sheep and rat.
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Inter-species investigation of the mechano-regulation of bone healing: comparison of secondary bone healing in sheep and rat.

机译：骨愈合机械调节的物种间调查：绵羊和大鼠继发性骨愈合的比较。

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Inter-species differences in regeneration exist in various levels. One aspect is the dynamics of bone regeneration and healing, e.g. small animals show a faster healing response when compared to large animals. Mechanical as well as biological factors are known to play a key role in the process. However, it remains so far unknown whether different animals follow at all comparable mechano-biological rules during tissue regeneration, and in particular during bone healing. In this study, we investigated whether differences observed in vivo in the dynamics of bone healing between rat and sheep are only due to differences in the animal size or whether these animals have a different mechano-biological response during the healing process. Histological sections from in vivo experiments were compared to in silico predictions of a mechano-biological computer model for the simulation of bone healing. Investigations showed that the healing processes in both animal models occur under significantly different levels of mechanical stimuli within the callus region, which could explain histological observations of early intramembranous ossification at the endosteal side. A species-specific adaptation of a mechano-biological model allowed a qualitative match of model predictions with histological observations. Specifically, when keeping cell activity processes at the same rate, the amount of tissue straining defining favorable mechanical conditions for the formation of bone had to be increased in the large animal model, with respect to the small animal, to achieve a qualitative agreement of model predictions with histological data. These findings illustrate that geometrical (size) differences alone cannot explain the distinctions seen in the histological appearance of secondary bone healing in sheep and rat. It can be stated that significant differences in the mechano-biological regulation of the healing process exist between these species. Future investigations should aim towards understanding whether these differences are due to differences in cell behavior, material properties of the newly formed tissues within the callus and/or differences in response to the mechanical environment.
机译：各种水平的物种间再生差异存在。一个方面是骨再生和愈合的动态，例如愈合。与大型动物相比，小动物显示出更快的愈合响应。已知机械以及生物因素在该过程中发挥关键作用。然而，它仍然是迄今未知不同的动物是否在组织再生期间在所有相当的机械生物学规则中遵循，特别是在骨愈合期间。在这项研究中，我们研究了在大鼠和绵羊之间的骨愈合的动态中在体内观察到的差异是由于动物尺寸的差异或这些动物是否在愈合过程中具有不同的机械生物反应。在体内实验中的组织学部分与用于模拟骨愈合的机械生物计算机模型的硅预测。研究表明，两种动物模型中的愈合过程在愈伤组织区域内的机械刺激水平显着不同，这可以解释在内皮内侧的早期肠腔骨化的组织学观察。机械生物模型的特异性调整允许使用组织学观察进行模型预测的定性匹配。具体地，当以相同的速率保持细胞活性过程时，在大型动物的大型动物模型中，在大型动物模型中，在大型动物模型中，可以增加限定骨骼的有利机械条件的组织紧张的量，以实现模型的定性协议用组织学数据预测。这些发现表明，单独的几何（尺寸）差异不能解释在绵羊和大鼠中的继发性骨愈合的组织学外观中看到的区别。可以说，这些物种之间存在愈合过程的机械生物学调节的显着差异。未来的调查应旨在理解这些差异是否是由于细胞行为的差异，愈伤组织内愈伤组织内的新形成的组织的材料特性和/或响应机械环境的差异。

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