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首页> 外文期刊>Journal of Biomechanics >Determination of the relationship between collagen cross-links and the bone-tissue stiffness in the porcine mandibular condyle.
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Determination of the relationship between collagen cross-links and the bone-tissue stiffness in the porcine mandibular condyle.

机译：猪颌骨髁上胶原交联与骨组织刚度的关系。

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Although bone-tissue stiffness is closely related to the degree to which bone has been mineralized, other determinants are yet to be identified. We, therefore, examined the extent to which the mineralization degree, collagen, and its cross-links are related to bone-tissue stiffness. A total of 50 cancellous and cortical bone samples were derived from the right mandibular condyles of five young and five adult female pigs. The degree of mineralization of bone (DMB) was assessed using micro-computed tomography. Using high-performance liquid chromatography, we quantified the collagen content and the number of cross-links per collagen molecule of two enzymatic cross-links: hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP), and one non-enzymatic cross-link: pentosidine (Pen). Nanoindentation was used to assess bone-tissue stiffness in three directions, and multiple linear regressions were used to calculate the correlation between collagen properties and bone-tissue stiffness, with the DMB as first predictor. Whereas the bone-tissue stiffness of cancellous bone did not differ between the three directions of nanoindentation, or between the two age groups, cortical bone-tissue stiffness was higher in the adult tissue. After correction for DMB, the cross-links studied did not increase the explained variance. In the young group, however, LP significantly improved the explained variance in bone-tissue stiffness. Approximately half of the variation in bone-tissue stiffness in cancellous and cortical bone was explained by the DMB and the LP cross-links and thus they cannot be considered the sole determinants of the bone-tissue stiffness.
机译：虽然骨组织刚度与骨矿化的程度密切相关，但尚未识别其他决定簇。因此，我们检查了矿化度，胶原蛋白及其交联与骨组织刚度有关的程度。总共50个松散和皮质骨样品源自五个年轻和五个成年女性猪的右颌骨髁。使用微计算断层扫描评估骨（DMB）的矿化程度。使用高效液相色谱法，我们量化了两种酶联交联的每个胶原蛋白分子的胶原蛋白含量和交联的数量：羟基氰基吡啶啉（HP）和赖氨酸吡啶啉（LP），以及一种非酶联交叉链接：戊糖苷（钢笔）。用于评估三个方向的骨组织刚度，使用多元线性回归来计算胶原性能与骨组织刚度之间的相关性，其中DMB作为第一预测值。虽然松质骨的骨组织刚度在纳米狭窄的三个方向之间没有差异，或者在两个年龄组之间，成人组织的皮质骨组织刚度较高。在对DMB进行校正后，研究的交叉链接未增加解释的方差。然而，在幼体中，LP显着改善了骨组织刚度的说明方差。通过DMB和LP交联解释松质和皮质骨中骨组织刚度的大约一半的变化，因此它们不能被认为是骨组织刚度的唯一决定因素。

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