Theoretical and experimental evaluation of the effects of an argon gas mixture on the pressure drop through adult tracheobronchial airway replicas

Litwin Patrick D.; Dib Anna Luisa Reis; Chen John; Noga Michelle; Finlay Warren H.; Martin Andrew R.

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Theoretical and experimental evaluation of the effects of an argon gas mixture on the pressure drop through adult tracheobronchial airway replicas

机译：氩气混合物对通过成人气管支气道复制品压降的理论和实验评价

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Argon has the potential to be a novel inhaled therapeutic agent, owing to the neuroprotective and organoprotective properties demonstrated in preclinical studies. Before human trials are performed, an understanding of varying gas properties on airway resistance during inhalation is essential. This study predicts the effect of an 80% argon/20% oxygen gas mixture on the pressure drop through conducting airways, and by extension the airway resistance, and then verifies these predictions experimentally using 3-D printed adult tracheobronchial airway replicas.

机译：由于在临床前研究中证明的神经保护和有机防御性能，氩气有可能成为一种新型吸入治疗剂。在进行人类试验之前，在吸入期间对气道阻力进行不同的气体性质的理解是必不可少的。该研究预测了80％氩/ 20％氧气混合物在通过导电通气的压力下降的效果，并通过延长气道阻力，然后使用3-D印刷成人气管支气道复制品进行实验验证这些预测。

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来源
《Journal of Biomechanics》 |2017年第2017期|共5页
作者
Litwin Patrick D.; Dib Anna Luisa Reis; Chen John; Noga Michelle; Finlay Warren H.; Martin Andrew R.;
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作者单位

Cross Canc Inst Edmonton AB Canada;

Univ Alberta Mech Engn Edmonton AB Canada;

Univ Alberta Mech Engn Edmonton AB Canada;

Univ Alberta Radiol &

Diagnost Imaging Edmonton AB Canada;

Univ Alberta Mech Engn Edmonton AB Canada;

Univ Alberta Mech Engn Edmonton AB Canada;

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原文格式 PDF
正文语种 eng
中图分类生物医学工程;
关键词
Argon; Noble gas; Airway resistance; Conducting airways; Pressure drop; Pressure loss;

机译：氩气;高贵的气体;气道阻力;导通气道;压降;压力损失;

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专利

1. Theoretical and experimental evaluation of the effects of an argon gas mixture on the pressure drop through adult tracheobronchial airway replicas [J] . Litwin Patrick D., Dib Anna Luisa Reis, Chen John, Journal of Biomechanics . 2017,第期

机译：氩气混合物对通过成人气管支气道复制品压降的理论和实验评价
2. Experimental evaluation of pressure drop for flows of air and heliox through upper and central conducting airway replicas of 4-to 8-year-old children [J] . Paxman Tyler, Noga Michelle, Finlay Warren H., Journal of Biomechanics . 2019,第期

机译：通过4至8岁儿童的高中导电气道复制空气和中央升降机流量下降的实验评价
3. Experimental investigation of effects of grain size, inlet pressure and flow rate of air and argon on pressure drop through a packed bed of granular activated carbon [J] . Amir Mohammad Norouzi, Majid Siavashi, Amir Reza Soheili, International communications in heat and mass transfer . 2018,第AUGa期

机译：粒度，进气压力以及空气和氩气流速对颗粒状活性炭填充床压降影响的实验研究
4. FLOW DISTRIBUTION AND PRESSURE DROP IN STEADY AIRFLOW THROUGH A SELECTVE LASER SINTERED HUMAN TRACHEOBRONCHIAL AIRWAY MODEL [C] . Kah-Hoe Tan, Ramkumar N Parthasarathy, M. Cengiz Altan, Fluids Engineering Conference . 2003

机译：选择激光烧结人气管支气管通气模型在稳定气流中的流量分布和压降
5. EXPERIMENTAL AND THEORETICAL STUDIES IN LOW-TEMPERATURE PHYSICS: SUBLIMATION AND VAPOR PRESSURE OF ARGON-36 AND THE COMBINED EFFECTS OF PHONON ATTENUATION AND IMPEDANCE MATCHING ON KAPITZA RESISTANCE. [D] . OPSAL, JON LYNN. 1974

机译：低温物理领域的实验和理论研究：Arkon-36的叠加和蒸气压以及声子衰减和阻抗匹配对卡皮察抗性的综合影响。
6. Characterization of the thermotropic behavior and lateral organization of lipid-peptide mixtures by a combined experimental and theoretical approach: effects of hydrophobic mismatch and role of flanking residues. [O] . Sven Morein, J Antoinette Killian, Maria Maddalena Sperotto 2002

机译：通过组合的实验和理论方法表征脂肽混合物的热致行为和侧向组织：疏水错配的影响和侧翼残基的作用。
7. Binary gas adsorption on molecular sieves. Experimental data for the adsorption of oxygen, nitrogen and oxygen-nitrogen mixtures on five molecular sieve adsorbents at various temperatures and pressures and a comparison with theoretical models. [O] . Sorial George Ayad 1982

机译：分子筛上的二元气体吸附。在不同温度和压力下，氧，氮和氧氮混合物在五种分子筛吸附剂上的吸附实验数据，并与理论模型进行了比较。
8. Gas and Particle Deposition in Tracheobronchial Airways [R] . Cohen, B. S. 1987

机译：气管支气管内气体和颗粒沉积

Theoretical and experimental evaluation of the effects of an argon gas mixture on the pressure drop through adult tracheobronchial airway replicas

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