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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Healing bone lesion defects using injectable CaSO4/CaPO4-TCP bone graft substitute compared to cancellous allograft bone chips in a canine model
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Healing bone lesion defects using injectable CaSO4/CaPO4-TCP bone graft substitute compared to cancellous allograft bone chips in a canine model

机译：使用可注射的Caso4 / Capo4-TCP骨移植物替代犬模型的松质同种异体移植骨芯片治愈骨病变缺陷

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CaSO4/CaPO4-TCP bone graft substitute has been shown to be effective for treatment of bone lesion defects, but its mechanical, histological, and radiographic characteristics have not been studied in direct comparison with a conventional treatment such as cancellous allograft bone. Thirteen canines had a critical-size axial defect created bilaterally into the proximal humerus. CaSO4/CaPO4-TCP bone graft substitute (PRO-DENSE (TM), Wright Medical Technology) was injected into the defect in one humerus, and an equal volume of freeze-dried cancellous allograft bone chips was placed in the contralateral defect. The area fraction of new bone, residual graft, and fibrous tissue and the compressive strength and elastic modulus of bone within the defects were determined after 6, 13, or 26 weeks and correlated with radiographic changes. The data were analyzed using Friedman and Mann-Whitney tests. There was more bone in defects treated with the CaSO4/CaPO4-TCP bone graft substitute compared to defects treated with cancellous bone allograft at all three time points, and the difference at 13 weeks was significant (p = 0.025). The new bone was significantly stronger and stiffer in defects treated with the CaSO4/CaPO4-TCP bone graft substitute compared to defects treated with cancellous bone allograft at 13 (p = 0.046) and 26 weeks (p = 0.025). At 26 weeks, all defects treated with CaSO4/CaPO4-TCP bone graft substitute demonstrated complete healing with new bone, whereas healing was incomplete in all defects treated with cancellous allograft chips. The CaSO4/CaPO4-TCP bone graft substitute could provide faster and significantly stronger healing of bone lesions compared to the conventional treatment using freeze-dried cancellous allograft bone. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 107B: 408-414, 2019.
机译：Caso4 / Capo4-TCP骨移植物替代物已被证明是对治疗骨病变缺陷的有效，但其机械，组织学和放射线特性尚未与诸如松质同种异体移植骨的常规治疗直接进行研究。十三犬的临界轴向缺陷在近端肱骨中造成了双侧。 Caso4 / Capo4-TCP骨移植物替代品（Pro-Cense（TM），赖特医疗技术）注射到一个肱骨中的缺陷中，并且将相同体积的冷冻干燥的松土异链移植骨碎片置于对侧缺陷中。在6,13或26周后测定新骨，残余移植物和纤维组织的面积分数以及缺陷内的骨骼内的骨骼的抗压强度和骨骼弹性模量，并与射线照相变化相关。使用弗里德曼和曼恩惠特尼试验分析了数据。与Caso4 / Capo4-TCP骨移植物相比，在所有三个时间点处理的缺陷相比，用CasO4 / Capo4-TCP骨移植物替代缺陷，并且在13周的差异显着（P = 0.025）。与Caso4 / Capo4-TCP骨移植物替代的缺陷相比，新骨显着强烈，更静得与用松质骨同种异体移植物处理的缺陷（p = 0.046）和26周（p = 0.025）。在26周时，用CASO4 / CAPO4-TCP骨移植物替代品处处理的所有缺陷都表现出与新骨骼完全愈合，而用松质同种异体碎片处理的所有缺陷愈合不完整。与使用冷冻干燥的松软异种移植骨的常规治疗相比，CasO4 / Capo4-TCP骨移植物替代品可以提供更快的骨病变愈合。 （c）2018 Wiley期刊，Inc。J生物保解员B：Appl Biomater，107B：408-414,2019。

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