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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Biodegradable silk catheters for the delivery of therapeutics across anatomical repair sites
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Biodegradable silk catheters for the delivery of therapeutics across anatomical repair sites

机译：可生物降解的丝导管，用于跨解剖修复位点递送治疗剂

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Abstract Biodegradable silk catheters for the delivery of therapeutics are designed with a focus on creating porous gradients that can direct the release of molecules away from the implantation site. Though suitable for a range of applications, these catheters are designed for drug delivery to transplanted adipose tissue in patients having undergone a fat grafting procedure. A common complication for fat grafts is the rapid reabsorption of large volume adipose transplants. In order to prolong volume retention, biodegradable catheters can be embedded into transplanted tissue to deliver nutrients, growth factors or therapeutics to improve adipocyte viability, proliferation, and ultimately extend volume retention. Two fabrication methods are developed: a silk gel‐spinning technique, which uses a novel flash‐freezing step to induce high porosity throughout the bulk of the tube, and a dip‐coating process using silk protein solutions doped with a water soluble porogen. Increased porosity aids in the diffusion of drug through the silk tube in a controllable way. Additionally, we interface the porous tubes with ALZET osmotic pumps for implantation into a subcutaneous nude mouse model. The work described herein will discuss the processing parameters as well as the interfacing between pump and cargo therapeutic and the resulting release profiles. ? 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. ? 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 501–510, 2019.
机译：摘要可生物降解的丝导管，用于提供治疗方法，专注于创建多孔梯度，可以将分子释放远离植入部位。虽然适用于一系列应用，但这些导管设计用于药物递送以在经过脂肪移植程序的患者中移植脂肪组织。脂肪移植的常见并发症是大量脂肪移植的快速重吸收。为了延长体积保留，可生物降解的导管可以嵌入移植的组织中，以提供养分，生长因子或治疗剂以改善脂肪细胞的活力，增殖和最终延长体积保留。开发了两种制造方法：丝凝胶纺丝技术，它使用新的闪蒸步骤在整个管中诱导高孔隙率，以及使用掺杂有水溶性致孔剂的丝蛋白溶液的浸涂工艺。以可控的方式通过丝管增加药物扩散的孔隙率助剂。另外，我们用垃圾渗透泵接口多孔管以植入皮下裸鼠模型。这里描述的工作将讨论处理参数以及泵和货物治疗性和所得释放型材之间的接口。还2018 Wiley期刊，Inc.J生物保证Mater Res B：苹果生物摩特，2018年。？ 2018 Wiley期刊，INC.J生物保解员A型B：苹果生物粉末107B：501-510,2019。

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