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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Topical film prepared with Rhus verniciflua extract-loaded pullulan hydrogel for atopic dermatitis treatment
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Topical film prepared with Rhus verniciflua extract-loaded pullulan hydrogel for atopic dermatitis treatment

机译：用Rhus verniciflua提取物加载的pullulan水凝胶制备局部薄膜，用于特应性皮炎治疗

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摘要

Atopic dermatitis (AD) is characterized by relapsing pruritus and skin dryness. Due to the pathogenic multiplicity and the adverse effects associated with the current therapeutics, development of transdermal drug delivery system is becoming an area of interest. Here, a novel topical film prepared with Rhus verniciflua extract (RVE)-loaded pullulan hydrogel (RVE@PH) was synthesized and tested its therapeutic efficacy on the AD rats modeled by neonatal capsaicin injection method. The RVE@PH was characterized by a Fourier-transform infrared spectroscopy and an in vitro release assay. Rat pups were randomly divided into two groups: vehicle-treated (VEH; n = 5) and capsaicin-treated (n = 15). The latter were given capsaicin subcutaneously at 24 h after birth for AD induction and further divided into three groups (n = 5 per each): not treated (CAP), pullulan hydrogel-applied (PH), and RVE@PH-applied (RVE-PH). The pullulan hydrogel and RVE@PH were topically applied on shoulder lesions for 14 days (from 42 to 56 days after birth). Their phenotypes were compared based on the dermatitis score, epidermal thickness, mast cell infiltration, and serum myeloperoxidase (MPO) activities. The PH group showed significant attenuation in all the aforementioned values compared to the CAP group, suggesting that pullulan hydrogel itself has therapeutic activity against AD. Notably, the attenuations were more potent in the RVE-PH group than the PH group, indicating that the therapeutic efficacy against AD is augmented by the presence of RVE, a loaded pharmaceutic. Collectively, these results indicate that RVE@PH inhibits AD through exerting the dual roles, that is, the pullulan hydrogel-mediated physical and RVE-mediated pharmaceutical actions. (c) 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2325-2334, 2019.
机译：特征性皮炎（AD）的特征在于复发瘙痒和皮肤干燥。由于致病多重性和与目前治疗相关的不利影响，透皮药物递送系统的发育成为感兴趣的区域。这里，合成了用Rhus verniclua提取物（RVE） - 加载的鳞片水凝胶（RVE @ pH）制备的新型局部胶片，并在新生儿辣椒蛋白注射方法模拟的AD大鼠上测试其治疗效果。 RVE @ pH的特征在于傅里叶变换红外光谱和体外释放测定。将大鼠幼犬随机分为两组：载体处理（载体; n = 5）和辣椒素处理（n = 15）。后者在出生后24小时皮下给予辣椒素，以进行AD诱导，进一步分为三组（每项n = 5）：未治疗（盖子），普拉兰水凝胶 - 施用（pH），并持续@ pH施用（RVE -ph）。普拉兰水凝胶和RVE @ pH在肩部病变上局部施用14天（出生后42至56天）。将其表型基于皮炎评分，表皮厚度，肥大细胞浸润和血清髓氧化酶（MPO）活性进行比较。与帽组相比，pH组在所有上述值中显示出显着的衰减，表明蛋白水凝胶本身具有对AD的治疗活性。值得注意的是，衰减在RVE-pH组比pH组比pH组更有效，表明对AD的治疗效果是通过RVE的存在而增强了一种负载的药物。总的来说，这些结果表明RVE @ pH通过施加双重作用而抑制AD，即藜水凝胶介导的物理和rve介导的药物作用。 （c）2019 Wiley期刊，Inc。J生物保解率B：苹果生物机107B：2325-2334,2019。

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