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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Investigating the permeation properties of contact lenses and its influence on tear electrolyte composition
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Investigating the permeation properties of contact lenses and its influence on tear electrolyte composition

机译：研究隐形眼镜的渗透性及其对撕裂电解质组成的影响

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The health of the cornea is paramount; the aim of this study was to assess the permeation of essential tear electrolytes through a range of commercial contact lenses. Donor/receiver conductivity measurements were recorded using a dual-chamber diffusion system which allowed material permeability profiles and coefficients to be calculated. Water structuring properties of the contact lenses were measured by differential scanning calorimetry. Freezing water was subdivided into "ice-like" water (free, non-bound and has a melting point close to that of pure water) and polymer-associated water (free but loosely bound to the polymer matrix). Each material interacts differently with each of the three salts, for example; lotrafilcon B (34% equilibrium water content [EWC]) shows a higher and larger range of receiver concentrations post KCl, NaCl, CaCl2 permeation (76, 59 and 42 mM, respectively) compared with the lower and tighter range exhibited by lotrafilcon A (22% EWC) (36, 22, and 18 mM, respectively). Additionally, in terms of the relationship between permeation and water structure, balafilcon A (34% EWC) has a high KCl permeation (P-60 258 x 10(-8) cm(2)/s) and ice-like water (14%), but narafilcon A (44% EWC) has a low ion permeation (P-60 3.9 x 10(-8) cm(2)/s) and significantly less ice-like water (4%). The permeation trends for the silicone hydrogel materials could not be fully explained by water content and structuring. Composition and, in particular, the microstructure and morphology of these materials must impart a greater influence on permeation capability. (C) 2018 Wiley Periodicals, Inc.
机译：角膜的健康是至关重要的;本研究的目的是通过一系列商业隐形眼镜评估必需撕裂电解质的渗透。使用双室扩散系统记录供体/接收器电导率测量，该方法允许计算材料渗透性分布和待计算系数。通过差示扫描量热法测量隐形眼镜的水结构性质。冷冻水被细分为“冰状”水（自由，无束，靠近纯水的熔点）和聚合物相关的水（自由但松散地与聚合物基质结合）。例如，每个材料与三种盐中的每一个相互作用; Lotrafilcon B（34％平衡水含量[EWC]）显示出KCl，NaCl，CaCl2渗透（76,59和42mm）的较高且较大的接收器浓度与Lotrafilcon A（ 22％EWC）（分别为36,22和18 mm）。另外，就渗透和水结构之间的关系而言，BALAFILCON A（34％EWC）具有高KCL渗透（P-60 258×10（-8）cm（2）/ s）和冰状水（14 ％），但Narafilcon A（44％EWC）具有低离子渗透（P-60 3.9×10（-8）cm（2）/ s），并且冰状水显着较低（4％）。硅氧烷水凝胶材料的渗透趋势不能通过水含量和结构完全解释。组合物，特别是这些材料的微观结构和形态必须赋予对渗透能力的更大影响。 （c）2018 Wiley期刊，Inc。

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