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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >CoCr porous scaffolds manufactured via selective laser melting in orthopedics: Topographical, mechanical, and biological characterization
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CoCr porous scaffolds manufactured via selective laser melting in orthopedics: Topographical, mechanical, and biological characterization

机译：COCR多孔脚手架通过骨科选择性激光熔化制造：地形，机械和生物学特性

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摘要

Over the last decade, advances in additive manufacturing have allowed to obtain complex 3D porous lattice in materials suitable for orthopedic applications. Whereas 3D-melted titanium alloys have been extensively investigated, little is the current knowledge on the feasibility of bone-replicating CoCr porous scaffolds manufactured via selective laser melting (SLM). Moreover, the effect of topography on bone cells viability and proliferation has not been fully explored yet. Small cylindrical porous lattices were modeled from micro-CT images of human trabecular bone, and from the repetition of spherical-hollow and body-centered cubic unit cells, and manufactured via SLM from CoCr powder. Macro- and microcharacterization of the porous samples were assessed using optical microscope, micro-CT, and SEM. The scaffolds mechanical properties, measured via ISO testing, compared well with those of the human bone. Osteoblast-like cells proliferation and viability were assessed in vitro, and compared to those cultured on a standard nonporous implant-to-bone interface, showing steady increase on all geometries over time. SEM analysis confirmed the quality of cells morphology, spread, and organization on all lattices. The SLM process appeared not to alter the biocompatibility of CoCr; however, 15-100 mu m irregularities and macroalterations were observed in the porous scaffolds with respect to the 3D nominal models. (c) 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2343-2353, 2019.
机译：在过去十年中，添加剂制造的进展已经使得在适用于整形外科应用的材料中获得复杂的3D多孔格子。虽然3D熔化的钛合金已被广泛调查，但目前关于通过选择性激光熔化（SLM）制造的骨复制COCR多孔支架可行性的知识。此外，尚未完全探索地形对骨细胞活力和增殖的影响。小圆柱形多孔格子由人小梁骨的微型CT图像建模，并从重复球形中空和体为中心的立方单元电池，并通过来自COCT粉末的SLM制造。使用光学显微镜，微型CT和SEM评估多孔样品的宏观和微特化。通过ISO测试测量的支架机械性能，与人骨的孔相比。在体外评估成骨细胞样细胞增殖和活力，并与在标准的无孔注入对骨界面上培养的那些相比，随着时间的推移显示所有几何形状的稳定增加。 SEM分析证实了所有格子的细胞形态，传播和组织的质量。 SLM过程出现不改变COCT的生物相容性;然而，在多孔支架上相对于3D标称模型在多孔支架中观察到15-100μm不规则性和致癌。 （c）2019 Wiley期刊，Inc.J生物保解员A部分B：苹果生物粉末107B：2343-2353,2019。

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